Training to Enhance Alignment of Psychiatry and Neuroscience

加强精神病学和神经科学协调的培训

• 批准号: 10591484
• 负责人: William A. Carlezon
• 金额: $ 37.65万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10591484
• 关键词: Neurosciences; Psychiatry; Training

SUMMARY This postdoctoral training program at McLean Hospital is designed to address gaps in psychiatry and neuroscience training that limit effective communication across disciplines and translation of discoveries into new treatments. In psychiatry, rapid advances in technology are changing the ways in which psychiatric illness is diagnosed, treated, and studied. In humans, continued refinements in brain imaging, increasing utilization of smart devices, and improvements in the efficiency of genetic tools are among developments enabling fundamentally new insights into healthy and aberrant brain function, as well as molecular factors that contribute to vulnerability to illness. In animal model systems, there has been a corresponding evolution of precision molecular techniques to probe and dissect the neural circuitry underlying motivational and emotional behavior. Despite these advances, psychiatry and neuroscience continue to evolve in parallel, with precious few examples where the fields have aligned to produce transformative changes in human health. One indicator of this parallel evolution is stagnation in development of new treatments; indeed, difficulties in developing CNS drugs with new mechanisms have led to a massive divestment by industry. While many factors contribute to these failures, most are related to a lack of forward- (animal to human) and back- (human to animal) translation of key discoveries, leading to questions about the usefulness of model systems in drug development. Enhancing alignment of psychiatry and neuroscience is critical to invigorate translationally-relevant discoveries in clinical and basic research. With its combined clinical, research, and academic missions, McLean is optimally positioned to play a key role in establishing more impactful interactions between psychiatry and neuroscience. Research occurs in >100 labs across clinical, preclinical, and basic neuroscience programs that are intertwined, in adjacent labs or neighboring buildings, enabling routine interactions among clinicians, neuroscientists, and trainees (residents, postdocs, students). As a freestanding psychiatric hospital—perennially ranked #1 in this category—there is expertise in a broad range of NIMH-relevant domains. McLean has unique attributes, including the Institute for Technology in Psychiatry, to facilitate efforts to align research in humans and animals. This T32 program will provide resources for 6 slots per year to support activities for postdoctoral trainees across a range of experience levels for up to 3 years. The main objectives include (1) exposing a diverse group of trainees with backgrounds in clinical care to basic neuroscience research, and vice-versa, (2) providing comprehensive training that prioritizes emerging technologies such as digital phenotyping, biomarkers, and genetics to enable rigorous study of homologous endpoints in humans and animals, (3) ensuring a balanced experience via dual mentors with complementary expertise, and (4) leveraging the dual mentorship design to train emerging mentors. Progress towards these goals will be overseen by a McLean leadership team and an External Advisory Committee comprising world-renowned experts in psychiatry, neuroscience, training, and therapeutics development.

总结 姆克林医院的博士后培训计划旨在解决精神病学的差距， 神经科学培训，限制跨学科的有效沟通和发现转化为 新疗法在精神病学中，技术的快速进步正在改变精神疾病 被诊断、治疗和研究。在人类中，大脑成像的不断改进， 智能设备和遗传工具效率的提高是使 对健康和异常大脑功能的全新见解，以及有助于 to vulnerability脆弱to disease疾病.在动物模型系统中， 分子技术来探测和剖析动机和情绪行为背后的神经回路。 尽管有这些进步，精神病学和神经科学继续并行发展，但很少有实例 这些领域已经结合起来，为人类健康带来了变革性的变化。这种平行关系的一个指标是 进化是新疗法开发的停滞;事实上，开发具有新的 这些机制导致工业界大规模撤资。虽然有许多因素导致这些失败，但大多数 与缺乏关键发现的前向（动物到人类）和后向（人类到动物）翻译有关， 导致人们对模型系统在药物开发中的有用性提出质疑。加强协调 精神病学和神经科学是至关重要的，以振兴临床和基础 research.凭借其结合临床，研究和学术任务，姆克林是最佳定位发挥 在精神病学和神经科学之间建立更有影响力的互动方面发挥关键作用。研究发生 在100多个实验室中，临床，临床前和基础神经科学项目相互交织，在相邻的实验室中， 或邻近的建筑物，使得临床医生、神经科学家和受训者（居民， 博士后、学生）。作为一家独立的精神病医院-在这一类别中常年排名第一-有 在广泛的NIMH相关领域的专业知识。姆克林有独特的属性，包括研究所为 精神病学技术，以促进人类和动物研究的一致性。T32计划将 每年提供6个名额的资源，以支持各种经验的博士后学员的活动 最高可达3年。主要目标包括：（1）让具有不同背景的学员接触到 从临床护理到基础神经科学研究，反之亦然，（2）提供全面的培训， 优先考虑新兴技术，如数字表型，生物标志物和遗传学，以实现严格的研究 人类和动物的同源终点，（3）通过双导师确保平衡的体验， 互补的专业知识，以及（4）利用双重导师制设计来培训新的导师。进展 实现这些目标将由姆克林领导团队和外部咨询委员会监督 包括世界知名的精神病学、神经科学、培训和治疗开发专家。

项目成果

Cross species review of the physiological role of D-serine in translationally relevant behaviors.

• DOI: 10.1007/s00726-023-03338-6
• 发表时间: 2023-11
• 期刊: Amino acids
• 影响因子: 3.5

Unpacking the Biases That Shape the Apparent Foci in the Meta-analysis of Voxel-Based Neuroimaging Studies.

在基于体素的神经影像研究的荟萃分析中揭示形成明显病灶的偏差。

• DOI: 10.1016/j.biopsych.2022.06.021
• 发表时间: 2022
• 期刊: Biological psychiatry
• 影响因子: 10.6
• 作者: Chung,Yoonho

The link between static and dynamic brain functional network connectivity and genetic risk of Alzheimer's disease.

• DOI: 10.1016/j.nicl.2023.103363
• 发表时间: 2023
• 期刊: NEUROIMAGE-CLINICAL
• 影响因子: 4.2
• 作者: Sendi, Mohammad S. E.;Zendehrouh, Elaheh;Ellis, Charles A.;Fu, Zening;Chen, Jiayu;Miller, Robyn L.;Mormino, Elizabeth C.;Salat, David H.;Calhoun, Vince D.
• 通讯作者: Calhoun, Vince D.

Early life stress in male mice blunts responsiveness in a translationally-relevant reward task.

• DOI: 10.1038/s41386-023-01610-7
• 发表时间: 2023-11
• 期刊: NEUROPSYCHOPHARMACOLOGY
• 影响因子: 7.6
• 作者: Hisey, Erin E.;Fritsch, Emma L.;Newman, Emily L.;Ressler, Kerry J.;Kangas, Brian D.;Carlezon Jr, William A. A.
• 通讯作者: Carlezon Jr, William A. A.

Building an intentional and impactful summer research experience to increase diversity in mental health research.

• DOI: 10.1038/s41386-022-01461-8
• 发表时间: 2022-12
• 期刊: NEUROPSYCHOPHARMACOLOGY
• 影响因子: 7.6
• 作者: Folorunso, Oluwarotimi O.;White, Karen Burns;Alonso-Caraballo, Yanaira;Nowicki, Genevieve P.;Olson, Elizabeth A.;Pizzagalli, Diego A.;Carlezon, William A.;Ressler, Kerry J.;Chartoff, Elena H.
• 通讯作者: Chartoff, Elena H.