Integrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center Level

生物信息学共享资源(BSR)由授予维斯塔尔研究所的癌症中心支持拨款(CCSG)支持，与绝大多数癌症中心成员在多个研究项目上进行合作。作为BSR的研究专家和常务董事，我的职责是参与其中许多研究项目的所有步骤。全研究所对癌症相关研究的参与使我能够开发适用于多个项目的全面数据分析管道，并在执行针对特定研究定制的分析时重复使用所获得的结果，包括数据库、汇总和注释的数据集和其他综合资源。与特定于项目的研究工作相结合，这反过来也有助于现有的知识库，这种综合方法为将计算生物学方法应用于各种癌症相关研究提供了一个强大的科学环境，如应用程序中所展示的那样。

The Bioinformatics Shared Resource (BSR), supported by the Cancer Center Support Grant (CCSG) awarded to the Wistar Institute, collaborates with the vast majority of cancer center members on multiple research projects. My role as a Research Specialist and Managing Director of the BSR is to be engaged with all steps of many of those research programs. The institute-wide involvement in cancer-related studies allows me to develop comprehensive data analyses pipelines applicable across multiple programs, as well as to re-use obtained results, including databases, summarized and annotated datasets and other integrative resources, in carrying out analyses customized to particular studies. In combination with project-specific research efforts, which in turn also contribute to the existing knowledgebase, this integrative approach provides a robust scientific environment for applying methods of computational biology to various cancer-related studies as demonstrated in the application.