Precision Approach to healthCARE enrollment Site (PA CARES)

Precision Approach to Healthcare登记网站(PA CARE)将吸引来自 阿巴拉契亚上游农村到郊区和城市环境具有不同的社会人口学特征 他们接受匹兹堡大学医学中心(UPMC)的护理。最大的非营利性组织UPMC 美国的综合医疗服务系统，由22家医院、500家门诊机构、17家老年医院组成 社区，以及宾夕法尼亚州29个县地区的医疗保险计划(280万成员)以及部分 俄亥俄州和西弗吉尼亚州。我们将利用几个大规模的参与者招募和信息学计划 在匹兹堡大学招收17.5万名参与者参加精准医学倡议(PMI)队列 程序。在第一年，我们将迅速从我们的卫生系统研究中招募10,000名参与者 参与者注册表，目前包括已同意重新联系的&gt；101,000个人 参加研究性学习。我们正在进行的战略计划将支持参与和注册 2-5年级有16.5万人参加。我们与Wondros合作，这是一家基于设计思维的制作公司， 让宾夕法尼亚人参与研究的讲故事和消息传递计划(PIT+Me™)将定制为 向UPMC患者传达PA关怀信息。我们将继续与查迪斯集团合作 (项目管理)、TrialSpark(基于社交媒体的参与者招募和eScheduling)和Flipside 媒体(在线电子同意)，确保不同参与者在11岁时有效参与和登记 地理上分散在各种UPMC的中心(例如，产科分娩单位，急诊科， 紧急护理设施、诊所、医院)和社区(例如，巨鹰社区药房、城市 大匹兹堡联盟，&GT；150个组织)设置。我们在全国公认的信息学专业知识 从广泛的UPMC电子健康记录(EHR)中收集、协调、合并和管理数据 以及不同的研究来源和我们创建用于链接EHR的通用本体和数据模型的经验 国家NIH和PCORI资助的数据网络中的数据将使我们能够管理和存储登记的EHR和 其他数据，并按计划将其传输到PMI协调中心。我们的信息学工具也将 促进生物样品的收集、跟踪和运输至PMI生物库。我们良好的业绩记录 记录我们使用以下工具从单个医疗保健系统高效招收175K不同个人的能力 精简流程，并为成功实现采购经理人指数的更广泛目标作出贡献， 包括精准医学的进步。

The Precision Approach to healthCARE enrollment Site (PA CARES) will engage the 2.9 million patients from rural upper Appalachia to suburban and urban environments with diverse sociodemographic characteristics who receive care from the University of Pittsburgh Medical Center (UPMC). UPMC, the largest non-profit integrated health delivery system in the US, comprises 22 hospitals, >500 outpatient facilities, 17 senior communities, and a health insurance plan (2.8M members) in a 29-county region of Pennsylvania plus part of Ohio and West Virginia. We will leverage several large-scale participant recruitment and informatics initiatives at the University of Pittsburgh to enroll 175,000 participants in the Precision Medicine Initiative (PMI) Cohort Program. During Year 1, we will rapidly enroll 10,000 participants from our health system-wide Research Participant Registry that currently includes >101K individuals who have consented to be re-contacted about enrolling in research studies. Our ongoing strategic initiatives will support the engagement and enrollment of 165K participants in Years 2-5. Our work with Wondros, a design-thinking-based production company, on a storytelling and messaging program (Pitt+Me™) to engage Pennsylvanians in research will be customized to communicate the PA CARES message to UPMC patients. We will continue partnering with The Chartis Group (project management), TrialSpark (social media-based participant recruitment and eScheduling), and Flipside Media (online e-consent) to ensure the efficient engagement and enrollment of diverse participants at 11 geographically dispersed centers in a variety of UPMC (e.g., obstetrical delivery units, emergency departments, urgent care facilities, clinics, hospitals) and community (e.g., Giant Eagle community pharmacies, Urban League of Greater Pittsburgh, >150 organizations) settings. Our nationally recognized informatics expertise in collecting, harmonizing, merging, and curating data from the extensive UPMC electronic health record (EHR) and diverse research sources and our experience creating a common ontology and data model for linking EHR data in national NIH- and PCORI-funded data networks will enable us to curate and store enrollee EHR and other data and transmit them to the PMI Coordinating Center on schedule. Our informatics tools will also facilitate the collection, tracking, and shipment of biospecimens to the PMI Biobank. Our robust track record documents our ability to efficiently enroll 175K diverse individuals from a single healthcare system using streamlined processes and to contribute to the successful achievement of the broader goals of the PMI, including the advancement of precision medicine.