Cell Identity and Signaling Research Program (Project-001)

细胞识别和信令研究计划 项目摘要 自上次竞争性更新以来，长期存在的细胞生长和分化计划 自1993年以来一直存在，并重组为小区身份和信令(CIS)计划。作为对.的回应 在2009年CCSG审查中表达的关切，细胞生长和分化计划领导人，高级 领导层和执行委员会与外部执行委员会进行了全面的方案审查 咨询委员会。达成了一项共识，重组该方案以解决审查关切和 加强协作互动。重新组织和调整重点的CIS课程需要新的教员 招募以加强重组的计划和普渡大学癌症中心的使命 研究(PCCR)。重组后的独联体方案作为PCCR的核心组成部分 在癌细胞生物学方面的发现。为此，独联体利用普渡大学在 生物科学、药物化学、药剂学、兽医学和营养学 癌细胞生物学的关键课题。具体地说，独联体项目的总体任务是调查关键的 影响信号通路和基因表达程序的分子，并了解细胞 身份被确定或更改。CI成员致力于了解需要维护的内容 细胞认同和纠正癌细胞所经历的认同危机。独联体成员国代表7个 不同的普渡学院和5个学院，从26名成员发展到33名成员 自上次CCSG审查以来增加了14个新成员。独联体项目目前有一个 NCI和其他同行评审的癌症相关支持的投资组合约为430万美元(直接成本)。由于…… PCCR支持和独联体方案领导人发起的方案变化，独联体协作 出版物大幅增加，方案内出版物达到8%(增长约38%)和 计划间合作比例为25%(增长约68%)；机构间协作比例为17%，总体 强大的合作出版率约为43%。CIS计划的结构是为了解决蜂窝电话的问题 通过集中在两个主要研究簇的身份：信号和细胞生长控制和调节 基因表达。CI计划成员也有一个共同的目标，即专注于基础科学以确定 并对可转化为癌症解决方案的细胞过程的关键分子进行表征。这个 独联体成员国研究的生物专业知识和癌症靶点使他们能够在 CI计划和其他PCCR研究计划成员之间的合作，为 PCCR。

Cell Identity and Signaling Research Program Project Summary Since the last competitive renewal, the long standing Cell Growth and Differentiation Program, which had been in existence since 1993, was reorganized to the Cell Identity and Signaling (CIS) Program. In response to concerns expressed in the 2009 CCSG review, the Cell Growth and Differentiation Program Leaders, Senior Leadership, and Executive Committee conducted a full programmatic review in conjunction with the External Advisory Committee. A consensus was reached to reorganize the Program to address review concerns and enhance collaborative interactions. The reorganized and refocused CIS Program required new faculty recruitment to strengthen the reorganized Program and the mission of the Purdue University Center for Cancer Research (PCCR). The reorganized CIS Program serves the PCCR as the central component for basic discovery in cancer cell biology. To do this, CIS leverages Purdue University foundational strengths in the biological sciences, medicinal chemistry, pharmacy, veterinary medicine, and nutrition science, to address critical topics in cancer cell biology. Specifically, the overall mission of the CIS Program is to investigate key molecules that impact signaling pathways and gene expression programs, and to understand how cellular identity is determined or altered. CIS members are committed to understanding what is needed to maintain cellular identity and correcting the identity crisis that cancer cells undergo. The CIS membership represents 7 different Purdue academic departments and 5 colleges, and has grown from 26 members to 33 members through the addition of 14 new members since the previous CCSG review. The CIS Program has a current portfolio of ~$4.3 million (direct costs) of NCI and other peer-reviewed, cancer-related support. As a result of PCCR support and the programmatic changes initiated by the CIS Program Leaders, CIS collaborative publications have dramatically increased with intra-programmatic publications at 8% (~38% increase) and inter-programmatic at 25% (~68% increase); inter-institutional collaborations are at 17%, providing an overall strong collaborative publication rate of ~43%. The CIS Program is structured to address the issue of cellular identity by focusing on two major Research Clusters: Signaling and Cellular Growth Control and Regulation of Gene Expression. CIS Program members also share the common goal of focusing on basic science to identify and characterize key molecules for cellular processes that can be translated into cancer solutions. The biological expertise and cancer targets that CIS members study allow them to develop collaborations within the CIS Program and among members of the other PCCR Research Programs, adding considerable value to the PCCR.