Novel Research Findings on Environmental Asbestos Exposure

摘要 在石棉研究中发生了范式转变，迫使几个领域的专家 重新考虑目前的命名和我们对不同类型矿物质对健康影响的理解 纤维迫切需要将这些专家聚集在一起，审议这些对传统 研究石棉的方法，讨论新出现的需求，并调整我们的研究方法。的 拟议的会议通过与国家研究所协调， 职业安全和健康。使这次会议及时的问题包括，a）自然的发现 在美国几个州的基岩和冲积层中发现砷化物（NOA），以及围绕 B）最近的数据显示，矿物纤维 不符合“石棉”的严格监管定义，但对健康有影响，c） 来自ATSDR资助的利比流行病学研究计划（LERP）和儿童健康的新发现 暴露跟踪调查研究（CHIEFS），要求重新审视非癌症石棉 相关疾病，除了传统上使用癌症作为健康终点外， 确定石棉毒性，d）利比角闪石的新参考浓度（RfC）， 美国环保署根据数据建立的非癌症结果在非常低的暴露。新的RFC 可能会影响未来的风险评估，因为新的NOA暴露发生。会议在此提出， 申请将与NIOSH主办的关于命名的会议一起举行， 石棉纤维的特性，使我们有机会建立一个跨学科的 关于石棉致病特性的讨论。综合会议 将于2016年9月在华盛顿的李斯特山礼堂举行。1.5的暂定名称- NIOSH研讨会的第一天是“伸长矿物纤维术语和表征”。健康 会议的影响部分（此应用程序）也将是1.5天，并将被命名为，“小说研究 关于环境砷暴露的调查结果”。我们的目标是：（a）召集各国专家， 纤维致病性，最近的健康结果发现，和风险评估，以分享目前的状态， 来自学术界、联邦机构和公众的广泛的、综合的受众，以及B） 发起讨论，优先考虑我们如何有效地研究新出现的健康风险， 这是一个方便的方法，并具有保护公众健康的共同总体目标。

ABSTRACT There is a paradigm shift occurring in asbestos research that is forcing experts in several fields to reconsider the current nomenclature and our understanding of health effects of different types of mineral fibers. There is a critical need to bring these experts together to consider these challenges to the traditional ways of studying asbestos, to discuss the emerging needs, and to adapt our research approaches. The proposed conference addresses that critical need by coordinating with the National Institute for Occupational Safety and Health. Issues making this meeting timely include, a) discoveries of Naturally Occurring Asbestos (NOA) in bedrock and alluvial deposits in several states in the U.S., as well as around the world, with a footprint much larger than previously estimated, b) recent data showing that mineral fibers that do not meet the strict regulatory definition of “asbestos” nevertheless have health consequences, c) novel findings from ATSDR-funded Libby Epidemiology Research Program (LERP) and Childhood Health Exposure Follow-up Investigation Study (CHIEFS) which mandate a new look at non-cancer asbestos related disease, in addition to the traditional use of cancer as the health end point most often used to determine asbestos toxicity, d) the new reference concentration (RfC) for Libby Amphibole which has been established by the EPA based on data showing non-cancer outcomes at very low exposures. The new RfC may impact future risk assessment as new NOA exposures occur. The conference proposed in this application will be held in conjunction with a NIOSH-sponsored meeting regarding nomenclature and characterization of asbestos fibers, giving us the perfect opportunity to establish an interdisciplinary discussion regarding the characteristics of asbestos that cause disease. The overall combined conference will take place in September 2016, at Lister Hill Auditorium in Washington, DC. The working title for the 1.5- day NIOSH workshop is, “Elongate Mineral Fiber Terminology and Characterization”. The health effects portion of the conference (this application) will also be 1.5 days, and will be titled, “Novel Research Findings on Environmental Asbestos Exposure”. Our aims are to: a) bring together national experts in fiber pathogenicity, recent health outcomes discoveries, and risk assessment to share the current state of the science with a broad, combined audience from academia, federal agencies, and the public, and b) initiate discussions that will place priorities on how we can study emerging health risks efficiently, expediently, and with the shared overall goal of protecting public health.