Lipopeptide antibiotics for XDR Gram-negative infections

多粘菌素被认为是多药耐药(MDR)和极耐药(XDR)革兰氏阴性感染的最后治疗选择。不幸的是，对这些抗生素的耐药性正在迅速发展，没有有效的治疗方法，导致患者死亡。该项目旨在开发一种作用光谱更好、安全性更好的抗生素，与多粘菌素相比，具有抗多粘菌素耐药性的活性。

The polymyxins are a drug class considered to be a last-resort treatment option for multidrug-resistant (MDR) and extremely drug resistant (XDR) Gram-negative infections. Unfortunately resistance is rapidly developing against these antibiotics, leaving no effective therapies and resulting in patient death. This project aims to develop an antibiotic with superior spectra of action and improved safety profiles compared to the polymyxins, with activity against polymyxin-resistant bacteria.