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SPIRRIT-HFPEF - DCC

SPIRRIT-HFPEF - DCC
SPIRRIT-HFPEF - DCC
批准号：
9217488
负责人：
Kevin J Anstrom
金额：
$33.42万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
项目状态：
已结题
起止时间：
2017-09-15 至 2022-07-31
来源：
https://reporter.nih.gov/project-details/9217488
关键词：
AdultAffectAldosterone AntagonistsCardiacCardiovascular systemCase Report FormCause of DeathCessation of lifeClinicalClinical ResearchClinical TrialsClinical Trials Data Monitoring CommitteesClinical effectivenessCommunitiesCommunity PracticeCommunity of PracticeComplexDataData Coordinating CenterData ElementData QualityData SetDevelopmentEFRACElectronic Health RecordElementsEnrollmentFosteringGeneric DrugsGoalsHealth Care CostsHealthcareHeart ArrestHeart failureHospitalizationInterventionIntervention TrialInvestigationLeadershipLeft Ventricular Ejection FractionLifeMichiganMineralocorticoid ReceptorMorbidity - disease rateNational Heart, Lung, and Blood InstituteNorth AmericaOutcomePatient RecruitmentsPatientsPharmaceutical PreparationsPlacebosPrevalencePublic HealthRandomizedRandomized Clinical TrialsRandomized Controlled TrialsRegistriesResearch InstituteResearch PersonnelScheduleSouth AmericaSpecific qualifier valueSpironolactoneStatistical Data InterpretationStructureSwedenTelephoneTestingTherapeuticTherapeutic InterventionTimeTreatment EfficacyUnited StatesUniversitiesUniversity Hospitalsaging populationbaseclinical research siteclinically relevantcompliance behaviorcostdata managementdesigneffective therapyevidence baseexperiencefollow-upimprovedmortalitynovelopen labelpatient populationpragmatic trialprimary outcomeprospectiverandomized trialsecondary outcomestandard of caresymptomatic improvementtooltreatment as usual

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中文摘要
翻译
安体舒通治疗心力衰竭的随机干预试验 射血分数（SPIRRIT-HFpEF）是一项务实的、基于注册的随机临床试验，旨在 评价螺内酯与常规护理的临床有效性。SPIRRIT的主要假设- HFpEF是指与常规治疗相比，螺内酯治疗可降低心血管死亡率。
英文摘要
Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFpEF) is a pragmatic, registry-based randomized clinical trial that proposes to evaluate the clinical effectiveness of spironolactone versus usual care. The primary hypothesis of SPIRRIT- HFpEF is that treatment with spironolactone will reduce cardiovascular mortality compared with usual care.
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TRANSFORM-HF DCC
  • 批准号：
    9768524
  • 项目类别：
  • 资助金额：
    $72.87万
  • 财政年份：
    2017
  • 负责人：
    Kevin J Anstrom
  • 依托单位：
    DUKE UNIVERSITY
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