Genomics

人类基因组测序彻底改变了癌症研究。基因组学核心是一个 机构共享资源，由科赫研究所和其他三个麻省理工学院单位共享， 中心成员在全基因组分析方面提供综合全面的服务。在前一时期， 这个核心（以前称为微阵列技术核心）专门关注基于微阵列的 技术.作为核心范围重组计划的一部分，该共享基因组核心的使命是 在当前时期大幅扩张。首先，核心承担了提供我们所有下一个 第二代测序能力（以前由生物聚合物和蛋白质组学核心提供）。二是 最近建立了以肿瘤学为重点的高通量小分子和shRNA筛选能力， CCSG发展和MIT基金的支持。核心还获得了新的仪器和一个 增加工作人员以支持这两项活动。在本报告所述期间， 中心成员，包括来自所有四个项目的研究人员。因此，这种共享资源至关重要。 科赫研究所使命的成功在未来的一段时间里，这一核心将继续提供广泛的 一系列最先进的全基因组技术，以支持科赫研究所的癌症研究使命。 值得注意的是，中心成员占核心服务总使用量的55%，但请求的CCSG 预算不到利益相关者捐款总额的50%。

The sequencing of the human genome has revolutionized cancer research. The Genomics Core is an Institutional Shared Resource, shared between the Koch Institute and three other MIT units, which provides Center Members with integrated and comprehensive services in genome-wide analyses. In the prior period, this Core (previously named the Microarray Technologies Core) focused specifically on microarray-based technologies. As part of a core-wide reorganization plan, the mission of this shared Genomics Core was greatly expanded in the current period. First, the Core took on the responsibility for providing all of our next generation sequencing capabilities (previously offered by the Biopolymers & Proteomics Core). Second, it recently established oncology-focused, high throughput small molecule and shRNA screening capabilities, with support from CCSG developmental and MIT funds. The Core also acquired new instrumentation and an expanded staff to support both of these activities. In the current period, the Core is used by more than 80% of the Center Members, including investigators from all four Programs. Thus, this Shared Resource is essential to the success of the Koch Institute mission. In the upcoming period, this Core will continue to offer a wide range of state-of-the-art genome-wide technologies to support the Koch Institute’s cancer research mission. Notably, Center Members represent 55% of the total usage of the Cores services, but the requested CCSG budget is less than 50% of the total stakeholder contributions.