Training in Immunological Mechanisms

摘要 该应用程序是培养博士后研究科学家在免疫机制有关， 自身免疫、炎症和传染病的发展和治疗。拉霍亚的节目 过敏和免疫学研究所（LJI）将包括来自LJI的20名教师，他们的专业知识是 免疫细胞功能与诸如糖尿病、炎症性肠病、多发性硬化症 哮喘、动脉粥样硬化、登革热、天花、巨细胞病毒和肺结核。每一位导师都是 国际公认的免疫学或免疫疾病领域，每一个都有实质性的同行- 审查研究经验和跟踪记录。该计划将开放给博士，医学博士和医学博士/博士 对免疫系统的基础和应用研究感兴趣的科学家。培训计划将包括一个 12-24个月的实验室工作经验，在一名或多名导师的密切监督下 致力于解决与免疫疗法相关问题的导师。导师的研究背景 是不同的，但共同的主题集中在免疫系统的初级细胞的生物学， 包括T细胞、B细胞、NKT细胞、巨噬细胞等。培训计划将代表一个 跨学科的方法，每个受训者都接触到最先进的免疫学 技术和系统，使免疫系统的基础和翻译发现。我们 目前和过去的受训人员都有出色的研究成果记录。将招募新学员 在全国范围内，将努力招募和留住特殊的少数民族，妇女和弱势群体。 候选人学员将根据他们以前的学习成绩，研究经验， 出版物、访谈和主管的推荐。学员将参加机构培训， 研讨会，期刊俱乐部，课程和免疫学会议，旨在扩大他们的广度， 了解免疫学和免疫疾病。所有受训人员将接受以下原则的指导： 负责任的研究和科学诚信。该计划的目标是促进发展 由多才多艺的免疫学家组成，他们可以填补急需的学术职位，可以竞争并成为 成功地获得独立的研究赠款，谁可以为生物技术和 药物方法，旨在治疗免疫相关疾病。

Abstract This application is to train post-doctoral research scientists in immunological mechanisms related to development and treatment of Autoimmune, Inflammatory, and Infectious Disease. The program at La Jolla Institute for Allergy and Immunology (LJI) will involve 20 faculty members from LJI whose expertise is in immune cell function that relates to diseases such as diabetes, inflammatory bowel disease, multiple sclerosis, asthma, atherosclerosis, dengue, smallpox, cytomegalovirus, and tuberculosis. Each faculty mentor is internationally recognized in the field of immunology or immunological disease and each has substantial peer- reviewed research experience and track records. The program will be open to PhD, MD, and MD/PhD scientists interested in basic and applied research of the immune system. The training program will consist of a bench research laboratory experience of 12-24 months, under the close supervision of a mentor or several mentors working on problems relevant to immunotherapy. The research backgrounds of the faculty mentors are diverse, but with common themes centered on the biology of the primary cells of the immune system, including T cells, B cells, NKT cells, macrophages, and others. The training program will then represent an interdisciplinary approach where each trainee is exposed to cutting edge and state-of-the-art immunological techniques and systems for making fundamental and translational discoveries of the immune system. Our current and past trainees have excellent records of research accomplishments. New trainees will be recruited nationwide and efforts will be made to recruit and retain exceptional minority, women, and disadvantaged candidates. Trainees will be chosen on the basis of their prior academic performance, research experience, publications, interviews, and recommendations from supervisors. Trainees will participate in institutional seminars, journal clubs, courses, and immunology conferences designed to expand the breadth of their understanding of immunology and immunological disease. All trainees will be instructed in the principles of responsible conduct of research and scientific integrity. The goals of the program are to foster the development of well-rounded immunologists who can fill much needed academic positions, who can compete and be successful in obtaining independent research grants, and who can contribute to biotechnology and pharmaceutical approaches, aimed at treatment of immune-related diseases.