2017 Cellular and Molecular Mechanism of Toxicology Gordon Research Conference and Gordon Research Seminar

摘要 基础分子毒理学的研究继续支持关键的创新和进步， 环境，制药和工业科学，努力阐明细胞，生物化学， 和有毒物质作用的基因组机制。国家和国际的步伐 环境和药物暴露的监管是迅速的， 物质对人类健康的影响正在迅速发展。2017年Gordon Research Conference（GRC） 在细胞和分子毒性机制（CMMT），我们专注于“机制毒理学： 机制毒理学高级研究”，其目标是将对 疾病的机制基础纳入风险决策和政策制定。2017年会议将以一个 广泛的主题，包括微生物组对毒理学结果的贡献， 毒性反应中的非编码RNA，异生素受体的新功能，遗传和 毒理学的表观遗传机制，CRISPR/Cas9等新技术的应用 毒理学研究中的系统生物学方法，以及非生物化学的新用途。 用于安全性和风险评估的传统体内模型。会议将汇集一个 一个跨学科的研究小组，他们处于各自领域的最前沿，并将提供 为初级科学家和研究生和本科生提供机会，介绍他们的工作， 海报和平台形式，并与该领域的领导人交流思想。学院的氛围 本次会议，安排了讨论会，并有机会举行非正式会议， 在下午和晚上，为来自不同学科的科学家提供了一条网络途径， 并促进各研究领域的合作。连续第三次，一个戈登 研究研讨会（GRS）将与本次会议同时举行。2017年GRS会议将 强调微生物组分析领域的最新进展，旨在进行安全性评估 了解毒性的机制。这是一个独特的论坛，研究生，博士后 研究员和其他具有可比经验和教育水平的科学家建立网络， 交流新的数据和前沿的想法。2017年的GRC将在周一增加一个新功能 下午：“电源小时：致力于包容和妇女的专业发展， 科学”，应对妇女在科学领域面临的挑战，并提供一个讨论论坛 和指导。

ABSTRACT Research in basic molecular toxicology continues to underpin key innovations and advances in environmental, pharmaceutical, and industrial sciences by striving to elucidate the cellular, biochemical, and genomic mechanisms of action of toxic substances. The pace of national and international regulation of environmental and pharmaceutical exposures is rapid and methods to assess the risk of substances to human health are rapidly advancing. For the 2017 Gordon Research Conference (GRC) in Cellular & Molecular Mechanisms of Toxicity (CMMT), we are focusing on “Mechanistic Toxicology: Advanced Investigation in Mechanistic Toxicology” with the goal of incorporating research on the mechanistic basis of disease into risk decision and policymaking. The 2017 Conference will feature a wide range of topics including the contribution of the microbiome to toxicological outcomes, the roles of the noncoding RNAs in toxic responses, novel functions of the xenobiotic receptors, genetic and epigenetic mechanisms of toxicology, new technologies such as the application of the CRISPR/Cas9 technology in toxicology research, systems biology approaches in toxicology, and novel uses of non- traditional in vivo models for safety and risk assessment. The conference will bring together an interdisciplinary group of investigators who are at the forefront of their field, and will provide opportunities for junior scientists and graduate and undergraduate students to present their work in poster and platform format and exchange ideas with leaders in the field. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to network and promotes collaborations in the various research areas. For the third consecutive time, a Gordon Research Seminar (GRS) will be held in conjunction with this conference. The 2017 GRS meeting will highlight recent advancements in the field of microbiome analysis, aimed towards safety assessment and understanding mechanisms of toxicity. This is a unique forum for graduate students, postdoctoral fellows, and other scientists with comparable levels of experience and education to network and present and exchange new data and cutting edge ideas. The 2017 GRC will add a new feature on Monday afternoon: “Power Hour: Committed to inclusion and the professional development of women in science”, addressing the challenges that women face in science and providing a forum for discussion and mentoring.