Conference and Workshop on New Frontiers in diagnosis, screening and management of inherited cancer syndromes

 描述（由申请人提供）：基因和基因组技术的快速发展彻底改变了我们对癌症风险评估、筛查、预防和靶向癌症治疗的方法，预示着精准医疗时代的到来。引入负担得起的下一代测序（NGS）测试，包括多基因组和全外显子组或基因组测序，提供了关于罕见和常见遗传变异的丰富数据。虽然这些技术可以实现个性化的癌症风险评估和癌症预防，但它们也需要新的方法来进行遗传咨询，解释结果和负责任地传达这种复杂的信息。虽然基因组学技术和应用于临床护理的专业教育是迫切需要的，特别是对社区从业人员和学员来说，它并不容易获得，也没有机会进行基于实践的案例学习。为了应对不断变化的环境并提供循证专业教育，我们提出了一个独特的跨学科年度会议系列，以突出癌症风险评估和预防方面的临床创新。该格式将包括最先进的讲座，小组讨论，小型分组会议的案例为基础的学习和海报展示。我们的总体目标是通过提供一个跨学科的教育论坛来提高癌症风险评估和精确预防方法的质量，在该论坛中传播转化基因组学的新知识，并为高危患者及其高危家庭成员提供循证临床护理。除了我们的领导团队外，还有一个会议咨询委员会（CAC），由在癌症遗传学方面具有卓越专业知识的外部成员组成，他们将为会议议程和发言人提供建议。每年，我们将邀请不同的教师谁是在各自领域的专家提供最先进的讲座，并参加小组和案例讨论。在随后的每一次会议上，我们将通过传播该领域研究和临床发展前沿的最新信息来实现我们的具体目标。为了建立一个学习社区，我们将策划由研讨会参与者提交的附带临床信息的谱系，并发表年度会议论文集。我们的目标受众包括癌症患者的跨学科医疗保健提供者（肿瘤学家，胃肠病学家，妇科医生，初级保健医生和外科医生），护士，医生助理和来自社区和学术实践的遗传咨询师。通过提供基于成绩和需求的旅行奖励，我们将为受训人员、初级调查员、妇女和少数民族提供特别机会，使他们能够充分参与讲习班，并与高级导师一起发表论文。地点将在芝加哥市中心（2016年，2018年和2020年）和加利福尼亚州杜阿尔特的希望之城（2017年和2019年）之间交替。通过跟踪一些指标，并由于精密医疗保健的新兴领域的动态性质，我们将改变我们的会议议程，以适应新的发展，并保持最新和相关的临床实践。

 DESCRIPTION (provided by applicant): Rapid advances in genetic and genomic technologies have revolutionized our approach to cancer risk assessment, screening, prevention and targeted cancer therapies, heralding the era of precision healthcare. The introduction of affordable next generation sequencing (NGS) testing including multi-gene panels and whole exome or genome sequencing provides a wealth of data on both rare and common genetic variants. While these technologies enable personalized cancer risk assessment and cancer prevention, they also require novel approaches to genetic counseling, interpretation of results and responsible communication of this complex information. While professional education in the technology and application of genomics to clinical care is urgently needed especially for community practitioners and trainees, it is not readily available and there are no opportunities for hands-on case based learning. To address the changing landscape and provide evidence-based professional education, we propose a unique interdisciplinary yearly conference series to highlight clinical innovations in cancer risk assessment and prevention. The format will include state-of the art lectures, panel discussions, small breakout sessions for case based learning and poster presentations. Our overall goal is to improve the quality of cancer risk assessment and precision prevention approaches by providing an interdisciplinary educational forum in which to disseminate new knowledge in translational genomics and evidence-based clinical care of high-risk patients and their at risk family members. In addition to our leadership team, a conference advisory committee (CAC) composed of external members with exceptional expertise in cancer genetics, who will advise on the conference agendas and speakers. Each year, we will feature different invited faculty who are experts in their field to provide state-of- the-art lectures and participate in panel and case discussions. At each subsequent conference, we will address our specific aims by disseminating updates at the cutting edge of research and clinical developments in the field. To develop a learning community, we will curate Pedigrees with accompanying clinical information submitted by workshop participants and publish an annual conference Proceedings. Our target audience includes interdisciplinary health care providers for cancer patients (oncologists, gastroenterologists, gynecologists, primary care physicians and surgeons), nurses, physician assistants and genetic counselors from community and academic practices. By offering merit- and need-based travel awards, we will provide special opportunities for trainees, junior investigators, women and minorities to participate fully in the workshops and publish with senior mentors. The locations will alternate between downtown Chicago (2016, 2018 and 2020) and City of Hope in Duarte, CA (2017 and 2019). By tracking a number of metrics and due to the dynamic nature of the emerging field of Precision Healthcare, we will alter our conference agenda to accommodate new developments and remain up-to-date and relevant to clinical practice.