Immunobiology of Trauma

这项T32拨款，GM86308，创伤免疫生物学将提供适当的培训和 指导造就下一代内科科学家。内科医生--科学家是关键 这是改善患者健康所必需的劳动力要素。因以下原因造成的伤亡 创伤性损伤是人们死亡和功能受损的主要原因 年龄在44岁以下。这种发病率和死亡率对医疗保健造成了不成比例的消耗 资源由于创伤患者的典型年轻年龄。此外，在这方面的新进展 慢性创伤性脑病(足球运动员脑损伤)鉴定范围展示 需要增加对创伤基础科学的投资。创伤不成比例 影响得不到充分服务的少数族裔患者，导致医疗保健差距，进一步强调 创伤在我们国家的健康中发挥着重要作用。我们竞争更新的这一版本将建立 关于前五年筹资取得的成功。这些成功包括有效的招聘 加入该计划的少数族裔医生，6个国家奖给我们的T32研究员，23篇论文 要么出版，要么出版。自2015年最初的续订提交以来，又增加了11 论文已经发表或正在印刷中。在这场竞争中有一些重要的创新 更新开发新的评估工具由新近资助的BU临床 科学与翻译研究所和美国国立卫生研究院新资助的少数民族辅导项目 学生，以及其他人。新应用程序中的一些重大变化包括 重组执行委员会，纳入有积极资金的成员和实验室， 制定明确的培训目标，并扩大培训队伍，以包括 调查人员专注于创伤性脑损伤。这笔赠款特别要求为两个 博士后研究员接受两年的培训，这一模式在 之前的资金。执行委员会与个别受训人员密切合作，以确定实验室 其研究与受训者的兴趣相符。我们之前所有的实习生都抽签了 来自波士顿医疗中心的住院医生计划，这是纽约最大的安全网医院 英国。有特殊的机构承诺体现在对 招聘和留住少数族裔残疾医生和实习生。应该指出的是 我们的10名实习生中只有一人完成了临床培训，而且不可能 记录成功完成我们项目的内科科学家。然而，我们已经准备好了 我们的受训人员通过指导他们的科学来从事学术生涯，这样他们已经 如众多国家奖项所记录的那样成功，并出版了多个 同行评议文献中的手稿。

This T32 grant, GM86308, Immunobiology of Trauma will provide the appropriate training and mentoring to create the next generation of physician scientists. Physician-scientists are a critical element of the workforce necessary to improve the health of patients. Injuries and deaths from traumatic injury represented the major cause of death and impaired function among people under the age of 44. This morbidity and mortality creates a disproportionate drain on healthcare resources due to the typical young age of the trauma patient. Additionally, new advances in identifying the scope of chronic traumatic encephalopathy (football players’ brain injury) show the need for increased investment in the basic science of trauma. Trauma disproportionately affects underserved minority patients resulting in healthcare disparities further emphasizing the role trauma plays in the health of our country. This revision of our competing renewal will build on the success of the prior five years of funding. These successes include effective recruitment of minority physicians into the program, 6 national awards to our T32 fellows, and 23 papers either published or in press. Since the original renewal submission in 2015 an additional 11 papers have been published or are in press. There are important innovations in this competing renewal which developing new evaluation tools developed by the recently funded BU Clinical Science and Translational Institute and a newly NIH funded mentoring program for minority students, among others. Some of the significant changes in the new application include a restructuring of the executive committee to include members with active funding and labs, development of clear training objectives, and expansion of the training faculty to include investigators focusing on traumatic brain injury. This grant specifically requests funding for two postdoctoral fellows for two years of training, a formula which has proven successful during the prior funding. The Executive Committee works closely with the individual trainees to identify labs whose research matches the interests of the trainees. All of our prior trainees have been drawn from the residency programs at Boston Medical Center, the largest safety net hospital in New England. There is exceptional institutional commitment manifest by the support for the recruitment and retention of minority physicians and trainees with disabilities. It should be noted that only one of our 10 trainees has completed their clinical training, and it is not possible to document successful physician scientists completing our program. However, we have prepared our trainees for academic careers by mentoring their science such that they have already been successful as documented by the numerous national awards and published multiple manuscripts in the peer reviewed literature.