Immunobiology of Trauma

创伤免疫生物学

• 批准号: 8501538
• 负责人: Daniel G. Remick
• 金额: $ 23.89万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8501538
• 关键词: Immunobiology; Trauma

DESCRIPTION (provided by applicant): This T32 training grant proposal will provide post-doctoral training in the field of trauma and peri-operative injury. Traumatic injury is one of the major causes for the loss of life, loss of productivity and loss of years of life. Compared to other processes such as cancer or cardiovascular disease, trauma frequently occurs in a younger age group with corresponding increased years of life lost. Trauma also disproportionately affects underserved and minority populations making trauma a health disparities issue. Currently, traumatic injury represents an unmet medical need. Against this background we intend to train physicians and scientists in basic methods of research so that they may be applied to study of traumatic injury. We will request support for 3 fellows per year, and each fellow will spend 2 years working closely with a research mentor. It is useful to consider the grant in terms of 2 groups: One group consists of the training faculty who will provide the education and the second group is composed of the fellows who will be trained. We are fortunate to have a strong cadre of currently funded, active and senior mentors who will participate in this grant. There are a total of 18 investigators and labs that have collectively trained more than 200 fellows over the past 10 years. The strength of the faculty must be considered un-paralleled. The trainees will come from both the clinical programs and also the direct application to individual labs. An emphasis will be placed on recruiting physicians in the current residency programs since Boston University has a strong track record in recruiting a diverse group of physicians and placing our fellows in academic positions. Based on institutional information there are currently several physicians in training who wish to participate in basic science training. Boston University School of Medicine has a rich tradition of serving the underserved which attracts a significant number of minority physicians to our clinical training programs. They will be a significant source of potential trainees. The training program will recruit from several clinical departments above and beyond the Department of Surgery. The training program is specifically designed to minimize formal coursework and maximize the interactions with the mentors. Potential trainees will be exposed on a frequent basis during their clinical rotations to the training opportunities provided by this program. The concept is that bright young, energetic minds directly observing clinical problems will be stimulated to closely examine the mechanisms which directly cause morbidity and mortality in the trauma patients. Patients who have suffered a traumatic injury and survive the initial insult have increased loss of life over the next several years. Substantial morbidity occurs over the remainder of the patients' lives. The impact of the initial traumatic injury extends far beyond the first event. This grant will train physicians and scientists in the study of how traumatic injury causes this increase in loss of life and loss of function.

描述（由申请人提供）：该 T32 培训拨款提案将提供创伤和围手术期损伤领域的博士后培训。外伤是造成生命损失、生产力损失和寿命损失的主要原因之一。与癌症或心血管疾病等其他过程相比，创伤经常发生在较年轻的年龄组，相应地损失的寿命也会增加。创伤也对服务不足的人口和少数族裔造成不成比例的影响，使创伤成为健康差异问题。目前，外伤代表着未满足的医疗需求。在此背景下，我们打算对医生和科学家进行基本研究方法的培训，以便将其应用于创伤性损伤的研究。我们每年将请求支持 3 名研究员，每位研究员将与一名研究导师密切合作 2 年。将补助金分为两组是有用的：一组由将提供教育的培训教师组成，第二组由将接受培训的研究员组成。我们很幸运拥有一支由目前资助的、活跃的高级导师组成的强大骨干队伍，他们将参与这项资助。在过去的10年里，总共有18个研究人员和实验室，总共培训了200多名研究员。师资力量必须被认为是无与伦比的。学员将来自临床项目，也将直接应用于各个实验室。由于波士顿大学在招募多元化的医生群体和将我们的研究员安排到学术职位方面拥有良好的记录，因此当前的住院医师计划将重点放在招募医生上。根据机构信息，目前有几名正在接受培训的医生希望参加基础科学培训。波士顿大学医学院有着为服务不足的人群提供服务的丰富传统，吸引了大量的少数族裔医生参加我们的临床培训项目。他们将成为潜在学员的重要来源。该培训计划将从外科以外的多个临床科室招募人员。该培训计划经过专门设计，旨在最大限度地减少正式课程作业并最大限度地提高与导师的互动。潜在的学员在临床轮转期间将经常接触到该计划提供的培训机会。这个概念是，将激发聪明、年轻、精力充沛的直接观察临床问题的头脑，仔细研究直接导致创伤患者发病和死亡的机制。遭受过创伤并在最初的伤害中幸存下来的患者在接下来的几年里生命损失不断增加。在患者的余生中会出现大量的发病率。最初的创伤性伤害的影响远远超出了第一次事件的范围。这笔赠款将培训医生和科学家研究创伤性损伤如何导致生命损失和功能丧失的增加。