Immunobiology of Trauma

描述（由申请人提供）：此T32培训资助提案将提供创伤和围手术期损伤领域的博士后培训。创伤性损伤是造成生命损失、生产力损失和寿命损失的主要原因之一。与癌症或心血管疾病等其他疾病相比，创伤通常发生在较年轻的年龄组，相应的寿命损失年数增加。创伤还不成比例地影响到服务不足和少数民族人口，使创伤成为一个健康差异问题。目前，创伤性损伤是一种未得到满足的医疗需求。在此背景下，我们打算培训医生和科学家的基本研究方法，以便他们可以应用于创伤性损伤的研究。我们每年将为3名研究员提供支持，每位研究员将与一名研究导师密切合作2年。将赠款分成两组考虑是有益的：一组由提供教育的培训教员组成，第二组由接受培训的研究员组成。幸运的是，我们有一个强大的骨干，目前资助，活跃和资深的导师将参与这项资助。在过去的10年里，共有18名研究人员和实验室总共培训了200多名研究员。教员的力量必须被认为是无与伦比的。学员将来自临床项目和直接应用到个别实验室。重点将放在当前住院医师项目中招聘医生，因为波士顿大学在招聘多样化的医生群体和将我们的研究员安置在学术职位方面有着良好的记录。根据机构信息，目前有几名正在培训的医生希望参加基础科学培训。波士顿大学医学院在服务弱势群体方面有着丰富的传统，这吸引了大量的少数族裔医生参加我们的临床培训项目。他们将是潜在受训人员的重要来源。培训计划将从外科以外的多个临床科室招聘。培训计划是专门设计的，以尽量减少正式课程，最大限度地提高与导师的互动。潜在的实习生将在他们的临床轮转中经常接触到这个项目提供的培训机会。其理念是，直接观察临床问题的聪明、年轻、精力充沛的头脑将被激发，以仔细研究直接导致创伤患者发病和死亡的机制。在接下来的几年里，遭受创伤性伤害并在最初的侮辱中幸存下来的患者的生命损失增加了。在病人的剩余生命中会出现大量的发病率。最初的创伤性伤害的影响远远超出了最初的事件。这笔拨款将培训医生和科学家研究创伤性损伤如何导致生命和功能丧失的增加。

DESCRIPTION (provided by applicant): This T32 training grant proposal will provide post-doctoral training in the field of trauma and peri-operative injury. Traumatic injury is one of the major causes for the loss of life, loss of productivity and loss of years of life. Compared to other processes such as cancer or cardiovascular disease, trauma frequently occurs in a younger age group with corresponding increased years of life lost. Trauma also disproportionately affects underserved and minority populations making trauma a health disparities issue. Currently, traumatic injury represents an unmet medical need. Against this background we intend to train physicians and scientists in basic methods of research so that they may be applied to study of traumatic injury. We will request support for 3 fellows per year, and each fellow will spend 2 years working closely with a research mentor. It is useful to consider the grant in terms of 2 groups: One group consists of the training faculty who will provide the education and the second group is composed of the fellows who will be trained. We are fortunate to have a strong cadre of currently funded, active and senior mentors who will participate in this grant. There are a total of 18 investigators and labs that have collectively trained more than 200 fellows over the past 10 years. The strength of the faculty must be considered un-paralleled. The trainees will come from both the clinical programs and also the direct application to individual labs. An emphasis will be placed on recruiting physicians in the current residency programs since Boston University has a strong track record in recruiting a diverse group of physicians and placing our fellows in academic positions. Based on institutional information there are currently several physicians in training who wish to participate in basic science training. Boston University School of Medicine has a rich tradition of serving the underserved which attracts a significant number of minority physicians to our clinical training programs. They will be a significant source of potential trainees. The training program will recruit from several clinical departments above and beyond the Department of Surgery. The training program is specifically designed to minimize formal coursework and maximize the interactions with the mentors. Potential trainees will be exposed on a frequent basis during their clinical rotations to the training opportunities provided by this program. The concept is that bright young, energetic minds directly observing clinical problems will be stimulated to closely examine the mechanisms which directly cause morbidity and mortality in the trauma patients. Patients who have suffered a traumatic injury and survive the initial insult have increased loss of life over the next several years. Substantial morbidity occurs over the remainder of the patients' lives. The impact of the initial traumatic injury extends far beyond the first event. This grant will train physicians and scientists in the study of how traumatic injury causes this increase in loss of life and loss of function.