Immunobiology of Trauma

描述(由申请人提供)：这项T32培训资助计划将提供创伤和围手术期损伤领域的博士后培训。创伤是造成生命损失、生产力损失和寿命损失的主要原因之一。与癌症或心血管疾病等其他过程相比，创伤往往发生在较年轻的年龄组，相应增加的寿命损失年数。创伤对服务不足和少数群体的影响也不成比例，使创伤成为一个健康差距问题。目前，创伤是一种未得到满足的医疗需求。在此背景下，我们打算对医生和科学家进行基本研究方法方面的培训，以便他们可以应用于创伤损伤的研究。我们将要求每年支持3名研究员，每个研究员将花2年的时间与一名研究导师密切合作。从两个方面考虑赠款是有用的：一组由将提供教育的培训教员组成，第二组由将接受培训的研究员组成。我们很幸运，我们有一支由目前资助的、积极的和资深的导师组成的强大干部队伍，他们将参与这笔赠款。在过去的10年里，共有18名研究人员和实验室总共培训了200多名研究员。教员的力量必须被认为是无与伦比的。学员将既来自临床项目，也来自于直接应用于个别实验室。由于波士顿大学在招募不同的医生群体和安排我们的研究员担任学术职位方面有着良好的记录，因此在当前的住院医师计划中将把重点放在招募医生上。根据机构信息，目前有几名医生正在接受培训，他们希望参加基础科学培训。波士顿大学医学院拥有为弱势群体服务的丰富传统，这吸引了相当多的少数族裔医生参加我们的临床培训计划。他们将是潜在受训人员的重要来源。培训计划将从外科以上和以外的几个临床科室招募人才。培训计划是专门设计的，旨在最大限度地减少正式的课程工作量，并最大限度地增加与导师的互动。潜在的受训人员将在临床轮换期间经常接触到本计划提供的培训机会。其概念是，聪明、年轻、精力充沛的头脑将被激发，直接观察临床问题，以仔细检查直接导致创伤患者发病率和死亡率的机制。在接下来的几年里，遭受创伤并在最初的侮辱中幸存下来的患者的生命损失增加了。在患者的余生中会出现大量的发病率。最初创伤性损伤的影响远远超出了第一次事件。这笔赠款将培训医生和科学家研究创伤性损伤如何导致生命损失和功能丧失的增加。

DESCRIPTION (provided by applicant): This T32 training grant proposal will provide post-doctoral training in the field of trauma and peri-operative injury. Traumatic injury is one of the major causes for the loss of life, loss of productivity and loss of years of life. Compared to other processes such as cancer or cardiovascular disease, trauma frequently occurs in a younger age group with corresponding increased years of life lost. Trauma also disproportionately affects underserved and minority populations making trauma a health disparities issue. Currently, traumatic injury represents an unmet medical need. Against this background we intend to train physicians and scientists in basic methods of research so that they may be applied to study of traumatic injury. We will request support for 3 fellows per year, and each fellow will spend 2 years working closely with a research mentor. It is useful to consider the grant in terms of 2 groups: One group consists of the training faculty who will provide the education and the second group is composed of the fellows who will be trained. We are fortunate to have a strong cadre of currently funded, active and senior mentors who will participate in this grant. There are a total of 18 investigators and labs that have collectively trained more than 200 fellows over the past 10 years. The strength of the faculty must be considered un-paralleled. The trainees will come from both the clinical programs and also the direct application to individual labs. An emphasis will be placed on recruiting physicians in the current residency programs since Boston University has a strong track record in recruiting a diverse group of physicians and placing our fellows in academic positions. Based on institutional information there are currently several physicians in training who wish to participate in basic science training. Boston University School of Medicine has a rich tradition of serving the underserved which attracts a significant number of minority physicians to our clinical training programs. They will be a significant source of potential trainees. The training program will recruit from several clinical departments above and beyond the Department of Surgery. The training program is specifically designed to minimize formal coursework and maximize the interactions with the mentors. Potential trainees will be exposed on a frequent basis during their clinical rotations to the training opportunities provided by this program. The concept is that bright young, energetic minds directly observing clinical problems will be stimulated to closely examine the mechanisms which directly cause morbidity and mortality in the trauma patients. Patients who have suffered a traumatic injury and survive the initial insult have increased loss of life over the next several years. Substantial morbidity occurs over the remainder of the patients' lives. The impact of the initial traumatic injury extends far beyond the first event. This grant will train physicians and scientists in the study of how traumatic injury causes this increase in loss of life and loss of function.