Immunobiology of Trauma

描述（由申请人提供）：此T32培训补助金提案将提供创伤和围手术期损伤领域的博士后培训。创伤是造成生命损失、生产力损失和寿命损失的主要原因之一。与癌症或心血管疾病等其他过程相比，创伤经常发生在较年轻的年龄组中，相应地增加了寿命损失。创伤也不成比例地影响服务不足和少数民族人口，使创伤成为健康差距问题。目前，创伤性损伤是一种未得到满足的医疗需求。在这种背景下，我们打算培训医生和科学家的基本研究方法，使他们可以应用于创伤性损伤的研究。我们将要求每年支持3名研究员，每个研究员将花2年时间与研究导师密切合作。将补助金分为两组是有益的：一组由提供教育的培训教师组成，第二组由将接受培训的研究员组成。我们很幸运，有一个强大的骨干目前资助，积极和高级导师谁将参加这项赠款。在过去10年中，共有18个调查员和实验室集体培训了200多名研究员。教师的力量必须被认为是不可忽视的。受训人员将来自临床项目和直接应用到各个实验室。重点将放在招聘医生在目前的住院医生计划，因为波士顿大学有一个良好的记录，在招聘一个不同的医生群体，并把我们的研究员在学术职位。根据机构信息，目前有几名正在接受培训的医生希望参加基础科学培训。波士顿大学医学院有着丰富的传统，为服务不足的人提供服务，吸引了大量的少数民族医生参加我们的临床培训课程。他们将成为潜在学员的重要来源。培训计划将从外科以上的几个临床科室招募人员。该培训计划是专门设计的，以尽量减少正式的课程，并最大限度地与导师的互动。潜在的受训者将在其临床轮换期间频繁接触本计划提供的培训机会。这个概念是，聪明的年轻人，精力充沛的头脑直接观察临床问题将受到刺激，以密切检查直接导致创伤患者发病率和死亡率的机制。遭受创伤并在最初的侮辱中幸存下来的患者在接下来的几年中增加了生命损失。在患者的余生中发生大量发病。最初的创伤性伤害的影响远远超出了第一次事件。这笔赠款将培训医生和科学家研究创伤如何导致生命损失和功能丧失的增加。

DESCRIPTION (provided by applicant): This T32 training grant proposal will provide post-doctoral training in the field of trauma and peri-operative injury. Traumatic injury is one of the major causes for the loss of life, loss of productivity and loss of years of life. Compared to other processes such as cancer or cardiovascular disease, trauma frequently occurs in a younger age group with corresponding increased years of life lost. Trauma also disproportionately affects underserved and minority populations making trauma a health disparities issue. Currently, traumatic injury represents an unmet medical need. Against this background we intend to train physicians and scientists in basic methods of research so that they may be applied to study of traumatic injury. We will request support for 3 fellows per year, and each fellow will spend 2 years working closely with a research mentor. It is useful to consider the grant in terms of 2 groups: One group consists of the training faculty who will provide the education and the second group is composed of the fellows who will be trained. We are fortunate to have a strong cadre of currently funded, active and senior mentors who will participate in this grant. There are a total of 18 investigators and labs that have collectively trained more than 200 fellows over the past 10 years. The strength of the faculty must be considered un-paralleled. The trainees will come from both the clinical programs and also the direct application to individual labs. An emphasis will be placed on recruiting physicians in the current residency programs since Boston University has a strong track record in recruiting a diverse group of physicians and placing our fellows in academic positions. Based on institutional information there are currently several physicians in training who wish to participate in basic science training. Boston University School of Medicine has a rich tradition of serving the underserved which attracts a significant number of minority physicians to our clinical training programs. They will be a significant source of potential trainees. The training program will recruit from several clinical departments above and beyond the Department of Surgery. The training program is specifically designed to minimize formal coursework and maximize the interactions with the mentors. Potential trainees will be exposed on a frequent basis during their clinical rotations to the training opportunities provided by this program. The concept is that bright young, energetic minds directly observing clinical problems will be stimulated to closely examine the mechanisms which directly cause morbidity and mortality in the trauma patients. Patients who have suffered a traumatic injury and survive the initial insult have increased loss of life over the next several years. Substantial morbidity occurs over the remainder of the patients' lives. The impact of the initial traumatic injury extends far beyond the first event. This grant will train physicians and scientists in the study of how traumatic injury causes this increase in loss of life and loss of function.