Integrated Biostatistical Training for CVD Research

项目名称：CVD研究的综合生物统计学培训 项目总结/摘要 这项申请提出更新一个新的，综合计划的博士前培训生物统计学 专注于培养学员从事心血管疾病研究的职业。不断升级的需求， 熟练的生物统计学家能够在这个激动人心的时代应对持续和新兴的挑战， 心血管疾病研究要求培训，正式整合深入和持续的经验， 在多学科环境中进行合作，掌握统计学的理论基础， 有效应用先进的生物统计技术和研究开发新的 方法论，并强调沟通和领导技能。该计划将是一个共同的努力 北卡罗来纳州州立大学（NCSU）统计系、杜克大学统计系 生物统计学和生物信息学（B&B）和杜克临床研究所（DCRI）。它利用了 两个部门之间的长期合作伙伴关系和一个医学研究机构，这是最大的 学术研究组织在世界上，与国际知名的研究人员在最前沿， 心血管疾病及相关研究。该五年计划将支持五（5）个实习生职位， NCSU部门，杜克大学B和B的一（1）年和二（2）年3-5职位。此外，本发明还提供了一种方法， NCSU，杜克和DCRI将提供两个，一个和两个匹配的位置在每年，分别。学员 在每个机构将追求统计理论的严格研究，包括概率，推理，线性和 其他统计模型，高级概率和高级统计推断;以及统计方法， 包括临床试验设计/分析，纵向数据分析，生存分析和前沿课题， 如记录链接、机器学习、与生物医学大数据相关并行计算等。他们还将 接受生物学和心血管医学基础方面的培训， 责任和道德;以及广泛的沟通和领导技能的正式和经验培训。 学员将逐步了解DCRI心血管疾病研究，并逐步发展到全面合作 他们将作为DCRI项目团队的职能成员参与学徒培训。通过这个 学徒和正式的课程和研讨会，学员将发展相当多的工作知识， 心血管药物，使他们能够立即为心血管疾病做出贡献 研究完成后，计划。每名学员将被分配一个跨机构的辅导小组 包括NCSU和B&B中的每一个的生物统计学家导师和临床医师导师，其主要隶属关系 是在DCRI，这将在指导他们通过各个方面的合作。论文研究将涉及 * 根据受训人员在培训中遇到的挑战，制定和评价新的统计方法 合作。学员将受益于接触到两个机构的不同文化， 他们的观点和获得课程，研讨会和其他资源。 !

Project Title: Integrated Biostatistical Training for CVD Research PROJECT SUMMARY/ABSTRACT This application proposes renewal of a novel, integrated program for predoctoral training in biostatistics focused on preparing trainees for careers in cardiovascular disease research. The escalating demand for skilled biostatisticians equipped to address ongoing and emerging challenges in this exciting era of cardiovascular disease research calls for training that formally integrates deep and sustained experience in collaboration in a multidisciplinary environment, mastery of the theoretical underpinnings of statistics required for valid application of sophisticated biostatistical techniques and for research on development of new methodology, and strong emphasis on communication and leadership skills. The program will be a joint effort of the Department of Statistics at North Carolina State University (NCSU), the Duke University Department of Biostatistics and Bioinformatics (B&B), and the Duke Clinical Research Institute (DCRI). It capitalizes on the long-standing partnership between the two departments and a medical research institution that is the largest Academic Research Organization in the world, with internationally known researchers at the forefront of cardiovascular disease and related research. The five-year program will support five (5) trainee positions in the NCSU Department and one (1) position in Years 1 and 2 and two (2) in Years 3-5 in Duke B&B. In addition, NCSU, Duke, and DCRI will provide two, one, and two matching positions in each year, respectively. Trainees at each institution will pursue rigorous study of statistical theory, including probability, inference, linear and other statistical models, advanced probability, and advanced statistical inference; and of statistical methods, including clinical trials design/analysis, longitudinal data analysis, survival analysis, and cutting-edge topics, such as record linkage, machine learning, parallel computing relevant to biomedical Big Data. They will also receive training in fundamental aspects of biology and cardiovascular medicine as well as research responsibility and ethics; and extensive formal and experiential training in communication and leadership skills. Trainees will be introduced to DCRI cardiovascular disease research gradually and evolve to full collaborative apprenticeships in which they are integrated as functioning members of DCRI project teams. Through this apprenticeship and formal courses and seminars, trainees will develop considerable working knowledge of cardiovascular medicine that will position them to make immediate contributions to cardiovascular disease research upon completion of the program. Each trainee will be assigned an inter-institutional mentorship team comprising a biostatistician mentor at each of NCSU and B&B and a clinician mentor whose primary affiliation is at DCRI, which will collaborate in guiding them through all aspects. Dissertation research will involve development and evaluation of novel statistical methodology inspired by challenges encountered in trainees' collaborations. Trainees will benefit from exposure to different cultures across both institutions, broadening their perspectives and access to courses, seminars, and other resources. !