Mentoring and Neuroimaging Research on White Matter Pathology in Schizophrenia

摘要 我是一名临床放射学家和神经科学家。我把我的研究 了解白色物质病理学的机制、性质和时间过程， 精神分裂症我是放射科和精神科的副教授 布里格姆妇女医院，哈佛医学院我也是一名助理 BWH精神病学系精神病学神经影像实验室主任， 作为精神病学系形态分析中心的联合主任， 马萨诸塞州总医院，我在那里有一个第二任命为研究 科学家自2003年以来，我一直在进行NIH赞助的研究，当时我 获得了我的第一个R 03奖。我目前是NIMH R 01奖的PI，专注于 脑卒中风险、发病和结局的新神经影像学生物标志物的开发 精神分裂症我也是NIA资助的R 01的PI，了解 大脑发育，成熟和衰老通过一套神经成像工具和他们的 在恒河猴中进行验证。这两项赠款加在一起有可能提供 经验证的神经影像学生物标志物，可用于诊断和监测 精神分裂症中由于髓鞘损失和神经炎症引起的神经生物学变化， 衰老，以及一系列其他神经精神疾病， 涉案除了我的研究，我还参与指导哈佛，麻省理工学院和波士顿大学 本科和研究生论文学生，博士后研究员（包括T32和 K23获奖者），外国研究员和暑期学生。我还参与了 作为BWH和MGH两个大型实验室的负责人， 地方和区域委员会。最后，我参与了非临床和非POR 研究（通过我正在进行的和悬而未决的动物项目），这需要从 我的指导和我的POR研究。K24可以保护时间，帮助我 专注于对我的职业发展最重要的-指导（30%），进一步培训 和新的POR（20%），而其余50%用于正在进行的神经影像学研究 白色物质生物标志物的变化在衰老和精神分裂症。

Abstract I am a clinical radiologist and neuroscientist by training. I have devoted my research career to understand mechanisms, nature and time-course of white matter pathology in schizophrenia. I am an Associate Professor in Departments of Radiology and Psychiatry at Brigham and Women’s Hospital, Harvard Medical School. I also serve as Associate Director of Psychiatry Neuroimaging Laboratory, Department of Psychiatry at BWH, and as a co-Director of Center for Morphometric Analysis, Department of Psychiatry, and Massachusetts General Hospital, where I have a secondary appointment as research scientist. I have been conducting an NIH sponsored research since 2003, when I received my first R03 award. I am currently PI on an NIMH R01 award, focusing on Development of New Neuroimaging Biomarkers of Risk, Onset and Outcome of Schizophrenia. I am also a PI on NIA funded R01 on understanding mechanisms of brain development, maturation and aging through a set of neuroimaging tools and their validation in rhesus monkeys. Those two grants together have the potential of delivering validated neuroimaging biomarkers, which could be used to diagnose and monitor neurobiological changes due to myelin loss and neuroinflammation in schizophrenia, aging, and a whole list of other neuropsychiatric diseases where those changes are involved. Besides my research, I am also involved in mentoring Harvard, MIT and BU undergraduate and graduate thesis students, postdoctoral fellows (including T32 and K23 awardees), foreign fellows, and summer students. I am also involved in administrative work, as head of two large laboratories, at BWH and at MGH, and various local and regional committees. Finally, I am getting involved in nonclinical and non-POR research (through my ongoing and pending animal projects), and that takes away from both my mentoring and my POR research. The K24 would protect time and help me to focus on most important for my career development- mentoring (30%), further training and new POR (20%), while devoting remaining 50% to ongoing neuroimaging research in biomarkers of white matter changes in aging and schizophrenia.