Integrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center Level

生物信息学共享资源（BSR）由授予Wistar研究所的癌症中心支持补助金（CCSG）支持，与绝大多数癌症中心成员合作开展多个研究项目。作为研究专家和BSR的董事总经理，我的角色是参与许多研究项目的所有步骤。在癌症相关研究的研究所范围内的参与使我能够开发适用于多个程序的综合数据分析管道，以及重新使用所获得的结果，包括数据库，总结和注释的数据集和其他综合资源，进行定制的分析特定的研究。结合特定项目的研究工作，这反过来也有助于现有的知识库，这种综合方法提供了一个强大的科学环境，将计算生物学方法应用于各种癌症相关的研究，如应用程序中所示。

The Bioinformatics Shared Resource (BSR), supported by the Cancer Center Support Grant (CCSG) awarded to the Wistar Institute, collaborates with the vast majority of cancer center members on multiple research projects. My role as a Research Specialist and Managing Director of the BSR is to be engaged with all steps of many of those research programs. The institute-wide involvement in cancer-related studies allows me to develop comprehensive data analyses pipelines applicable across multiple programs, as well as to re-use obtained results, including databases, summarized and annotated datasets and other integrative resources, in carrying out analyses customized to particular studies. In combination with project-specific research efforts, which in turn also contribute to the existing knowledgebase, this integrative approach provides a robust scientific environment for applying methods of computational biology to various cancer-related studies as demonstrated in the application.