Administrative Core

核心A -核心摘要： 本申请构成热带医学研究中心的延续申请 2007年和2012年授予印度瓦拉纳西的Banaras印度教大学。 参与的研究人员形成了一个由合作科学家组成的跨国网络， 在印度的比哈尔邦，致命疾病内脏利什曼病的关键方面。这个地区 印度内脏利什曼病流行率最高， 内脏利什曼病在全球蔓延。更新后的计划将建立在坚实的基础上， 在第一个TMRC计划中设立，包括来自比哈尔邦的111，999名受试者进入 一项重要的流行病学调查在了解这些问题方面取得了相当大的进展， 内脏利什曼病的流行病学、遗传学和免疫学风险已经形成了假设， 这一更新的应用程序是建立在这个基础上的。该计划将包括一个科学核心， 健康人口监测系统。提出了三个项目：（1）人类 在消除VL倡议背景下的流行病学，（2）病媒生物学研究，（3） 人VL中的免疫调节。该计划将在Banaras印度教大学协调， 通过行政核心以及数据管理和生物统计核心的努力。 该方案的具体目标是： 1.为一个科学核心、三个研究项目提供行政协调 以及TMRC计划的数据管理和生物统计核心。这将包括 与印度国内外机构的合作研究者进行沟通， 与NIH人员沟通，并确保符合NIH要求。 2.在穆扎法尔普尔的BHU、KAMRC提供财务会计和财务监督， 比利时热带医学研究所，QIMR Berghousehold医学研究所， 澳大利亚赫斯顿和美国爱荷华州大学。这将包括资金的分配， 工资的支付和费用的总体核算。 3.负责项目的日常管理。这将涉及购买和 分配设备和研究用品，管理人员，协调 出版物，并安排调查人员就具体项目进行沟通。 4.协调会议和培训活动。主要活动包括：（A）每年一次的培训管理审查委员会 会议在印度瓦拉纳西举行，与会的TMRC科学家和 来自BHU和Muzaffarpur的管理人员，以及来自其他 （B）印度学生的旅行和住房 研究者参加科学会议、短期课程或短期培训 在合作大学的实验室的经验。

Core A - Core Summary: This application constitutes a request for continuation of a Tropical Medicine Research Center that was awarded to Banaras Hindu University in Varanasi, India in 2007 and 2012. Participating investigators form a multi-national network of collaborating scientists studying critical aspects of the fatal disease, visceral leishmaniasis, in Bihar State, India. This region has the highest endemic rate of visceral leishmaniasis in India, and one of the highest rates of visceral leishmaniasis worldwide. The renewed program will build on the substantial foundation set up in the first TMRC program, including entry of 111,999 subjects from the state of Bihar into a substantial epidemiological survey. The considerable progress made in understanding the epidemiologic, genetic and immune risks for visceral leishmaniasis have formed the hypotheses upon which this renewed application is built. The program will include one scientific core, a Health Demographic Surveillance System. Three projects are proposed: (1) Human epidemiology in the context of the VL elimination initiative, (2) Vector Biological Studies, (3) Immune regulation in human VL. The program will be coordinated at Banaras Hindu University, through the efforts of the Administrative Core and the Data Management and Biostatistics Core. Specific aims of the program are: 1. To provide administrative coordination of the one scientific core, the three research projects and the Data Management & Biostatistics core of the TMRC program. This will include communication with collaborating investigators at institutions within and outside of India, communication with NIH personnel, and assurance of compliance with NIH requirements. 2. To provide financial accounting and oversight of finances at BHU, KAMRC in Muzaffarpur, Institute of Tropical Medicine, Belgium, QIMR Berghofer Medical Research Institute, Herston, Australia and the University of Iowa, USA. This will include distribution of funds, payment of salaries and overall accounting of expenses. 3. To perform the day to day management of the projects. This will involve purchase and distribution of equipment and research supplies, management of personnel, coordination of publications, and arranging communication between investigators on specific projects. 4. To coordinate meetings and training activities. Key activities are (A) the annual TMRC meeting in Varanasi, India, which is attended by participating TMRC scientists and administrators from BHU and Muzaffarpur, and by collaborating investigators from other universities in India, the USA, Australia and Belgium; (B) travel and housing for Indian investigators to participate in scientific meetings, short courses, or short term training experiences in labs at collaborating universities.