Testing the Effects of Anthrax Immune Globulin (AIG) in a Canine Model of B. anthracis Toxin Associated Shock

我们之前开发了一个ICU支持的犬炭疽杆菌毒素休克模型，该模型为LT和ET的致病作用提供了重要的见解。使用该模型，我们随后证明，在LT和ET单独或共同挑战时，虽然标准血流动力学的益处有限，但瑞希巴库提供了显著的益处，减少了液体和血管加压剂的需求，即使在低血压发作后给予，也能提高生存率。本研究的目的是确定在该犬模型中，在LT和ET挑战期间，AIG是否也增强了标准血流动力学支持。

We previously developed an ICU supported canine model of B. anthracis toxin shock, which has provided essential insights into the pathogenic effects of LT and ET. Using this model we then demonstrated that during LT and ET challenges alone or together, while the benefit with standard hemodynamic was limited, Raxibacumab provided substantial benefit, reducing fluid and vasopressor needs and improving survival even if administered after the onset of hypotension. The goal of the present study is to determine whether AIG also augments standards hemodynamic support during LT and ET challenge together in this canine model. Studies have been completed examining the effects of AIG in this canine model and a manuscript has been submitted an is presently under its first revision for Intensive Care Medicine Experimental. Work from this study was presented at the 2015 International Conference of the American Thoracic Society.