Bioinformatics/Biostatistics Core

生物信息学/生物统计学核心的目标是解决皮肤癌项目和核心的耶鲁大学孢子的统计和生物信息学分析需求。另一个主要目标是维护和扩展SPORE数据管理和分析系统（DMAS），用于跟踪生物标本和处理临床和实验数据。生物信息学/生物统计学核心的最终目标是提供符合SPORE数据和资源共享计划的数据。生物信息学/生物统计学核心的具体目标是目标1：维护和扩展SPORE数据管理和分析系统（DMAS），用于样本跟踪，以及存储和分析所有SPORE项目的临床和实验数据，目标2：SPORE项目数据的生物信息学和统计分析。对于目标1，我们将维护和扩展SPORE DMAS，该DMAS目前在caTissue中跟踪SPORE标本，使用caArray存储组学数据，并使用calntegrator进行数据集成和传播。核心还维护了一个专用的数据仓库，用于跨组学模式的综合数据分析。DMAS将紧密集成到SPORE标本资源核心中，并将满足SPORE项目成员的数据管理需求。DMAS将广泛利用耶鲁大学现有的信息系统和现有的caBIG技术。核心将强调与更广泛的皮肤癌社区的相互作用。对于目标2，生物信息学/生物统计学核心将解决从SPORE项目中产生的分析问题。核心小组提供的服务范围从规划活动到具体分析问题的咨询。更具体地说，核心将安排与SPORE研究者的定期会议，并对任何生物信息学/生物统计学问题保持开放政策。由于观察到的数据可能具有与假设不同的特征，Core将定期进行中期分析，动态更新把握度计算，根据需要开发新的统计和生物信息学方法，为SPORE研究者提供及时的建议，从而在整个研究中发挥重要作用。

The goal of the Bioinformatics/Biostatistics core is to address the statistical and bioinformatics analysis needs of the Yale SPORE in skin cancer projects and cores. Another major goal is the maintenance and extension of a SPORE Data Management and Analysis System (DMAS) for tracking of biological specimens and processing of clinical and experimental data. A final goal of the Bioinformatics/Biostatistics Core is the provision of data compliant with the SPORE data and resource-sharing plan. The specific aims of the Bioinformatics/Biostatistics Core are Aim 1: Maintenance and extension of a SPORE Data Management and Analysis System (DMAS) for specimen tracking, as well as storing and analyzing clinical and experimental data for all SPORE projects, and Aim 2: Bioinformatics and statistical analysis of SPORE project data. For Aim 1, we will maintain and extend the SPORE DMAS, which currently tracks SPORE specimens in caTissue, uses caArray for storing omics data and calntegrator for data integration and dissemination. The Core also maintains a dedicated data warehouse for integrative data analysis across omics modalities. DMAS will be tightly integrated Into the SPORE specimen resource core, and will serve the data management needs of the SPORE project members. DMAS will make extensive use of existing informatics systems at Yale University and existing caBIG technology. The Core will emphasis the Interactions with the wider skin cancer community. For Aim 2, the Bioinformatics/Biostatistics Core will address the analytic questions arising from the SPORE projects. Service provided by the Core will range from planning activities to consulting on specific analytic questions. More specifically, the Core will schedule regular meetings with the SPORE investigators, and maintain an open door policy for any bioinformatics/biostatistical questions. Since the observed data can have characteristics different from hypothesized, the Core will conduct regular interim analyses, dynamically update the power calculations, develop new statistical and bioinformatics methodology as needed, provide timely suggestions to SPORE investigators, and thus play an important role in the entire study.