Disability after ACL Reconstruction: Development of an Alternative Model of Care

项目摘要 骨关节炎（OA）是美国和世界范围内功能性残疾的主要原因。过早 在前交叉韧带损伤后， 韧带重建术（ACLR）。早在重建后7至15年， 个人发展膝关节OA，疼痛，功能残疾和生活质量下降的主要原因， 成年人的寿命。符合国家关节炎、肌肉骨骼和皮肤研究所的使命 疾病，这一建议将推进知识的原因，治疗和预防膝关节骨性关节炎， ACLR后的相关残疾。我们团队的长期目标是改善目前的护理模式， ACLR后的患者这项前瞻性研究将提供必要的关键数据，为未来有效的临床研究提供信息。 审判拟议的目标包括ACLR后结局的多模式检验。通过拟议的 目的，我们将获得关键知识，以指导我们未来的临床试验。

PROJECT SUMMARY Osteoarthritis (OA) is a leading cause of functional disability in the United States and worldwide. Premature development of knee OA is recognized with increasing frequency in young adults after anterior cruciate ligament (ACL) reconstruction (ACLR). As early as 7 to 15 years following reconstruction, a large majority of individuals develop knee OA, a major cause of pain, functional disability and decline in quality of life throughout the adult life-span. In line with the mission of the National Institute of Arthritis and Musculoskeletal and Skin Diseases, this proposal will advance knowledge into the causes, treatment, and prevention of knee OA and related disability after ACLR. The long-term objective of our team is to improve the current model of care for patients after ACLR. This prospective study will provide critical data needed to inform an effective future clinical trial. The proposed Aims incorporate multimodal testing of outcomes following ACLR. Through the proposed aims, we will obtain critical knowledge to guide our future clinical trial.