Integrative Cardiovascular Pathophysiology

描述（由申请人提供）：本更新申请要求为综合心血管病理生理学（ICVP）培训计划中的博士前和博士后学员提供支持。ICVP培训项目的教师导师在心血管研究中心（由ICVP项目主任Steven Houser博士指导）或坦普尔大学医学院转化医学中心（由ICVP项目联合主任Walter Koch博士指导）内任职。我们计划的目的是为综合心血管病理生理学（ICVP）领域的博士前研究员，博士后研究员和暑期医学生提供广泛的多学科培训经验。ICVP教职员工居住在许多不同的基础科学和临床部门，但他们的研究实验室位于CVRC和CTM内，位于新医学研究大楼的两个相邻楼层。ICVP研究者/导师对心血管系统的基本特性以及这些特性的异常变化有相关的兴趣，这些特性的异常变化会导致缺血性心脏病，高血压性心脏病，动脉粥样硬化，缺血性血管疾病，代谢综合征和糖尿病心血管疾病等疾病的心血管功能障碍。研究生和博士后研究员将接受人体生理学和病理生理学的教学培训，辅之以细胞和分子生物学的高级培训以及人类心血管疾病动物模型的适当使用。研究生和其他研究项目将有基本的和翻译的组成部分。学生和研究员们 将有望研究超越单一分子的问题，并在心血管疾病模型的背景下解决问题。这些项目的不同部分将在不同研究人员的实验室进行，确保学生和研究员接触到不同的科学方法。所有受训人员都将参加各种活动，以提高他们的赠款和手稿写作和口头交流技能。初级和高级教师的小组指导将确保学员有资格担任能够快速翻译的主要调查员职位 将新知识应用于临床实践。将采用各种招聘策略来吸引 多样化的学员群体，反映了我们国家的多样性。我们的目标是毕业于一个新的博士学位的多元化群体。和博士后研究员，能够满足国家对新的生物医学科学家的需求，提供下一代疗法，以减少心血管疾病的影响。

DESCRIPTION (provided by applicant): This renewal application requests support for pre- and post-doctoral trainees in an Integrated Cardiovascular Pathophysiology (ICVP) training program. Faculty mentors in the ICVP training program have their appointments within the Cardiovascular Research Center (Directed by Dr. Steven Houser, ICVP program director) or the Center for Translational Medicine (directed by Dr. Walter Koch, Co-Director of the ICVP program) at Temple University School of Medicine. The purpose of our program is to provide a broad based multidisciplinary training experience for pre- doctoral fellows, post-doctoral fellows and summer medical students in the area of integrative cardiovascular pathophysiology (ICVP). ICVP faculty members reside with many different basic science and clinical Departments, but their research laboratories are within the CVRC and CTM which are housed on two adjacent floors of a new medical research building. ICVP investigators/mentors have related interests in fundamental properties of the cardiovascular system and the aberrant changes in these properties that cause cardiovascular dysfunction in diseases including ischemic heart disease, hypertensive heart disease, atherosclerosis, ischemic vascular disease, metabolic syndrome and diabetic cardiovascular diseases. Graduate students and post-doctoral fellows will receive didactic training in human physiology and pathophysiology, complemented by advanced training in cellular and molecular biology and the appropriate use of animal models of human cardiovascular disease. Graduate student and fellow research projects will have basic and translational components. The students and fellows will be expected to investigate problems that go beyond a single molecule and address questions within the context of cardiovascular disease models. Different portions of these projects will be performed in the laboratories of different investigators, ensuring that students and fellows are exposed to different scientific approaches. All trainees will be involved in activities to enhance their grant and manuscript writing and oral communication skills. Group mentoring by junior and senior faculty will ensure trainees are well qualified to assume positions as leading investigators able to rapidly translate new knowledge into clinical practice. A variety of recruiting strategies will be used to attract a diverse group of trainees that reflect the diversity of our country. The goal is to graduate a diverse group of new Ph.Ds. and post-doctoral fellows that are able to fill a national need for new biomedical scientists to provide the next generation of therapies to reduce the impact of cardiovascular diseases..