Administrative and Statistical Core

摘要-行政和统计核心（负责人：Sallie Permar，杜克大学） 该方案的行政和统计核心目标是提供基础设施和监督， 确保该计划的科学目标得以实现，并对儿科艾滋病毒领域产生持久的影响， 1治愈。核心将负责确保科学计划的制定、实施， 在统计上得到支持，并将努力减轻该计划调查人员的行政负担。一致 基于这些目标，核心提出了以下具体目标：1）提供全面管理，协调， （2）提供及时的财务会计， 确保遵守机构、州和联邦研究指南; 3）执行适当的数据 管理和分析所有项目和核心，并开发影响因素的数学模型 出生后艾滋病毒感染的病毒反弹。作为目标3的一部分，统计负责人将使用 本程序对婴儿恒河猴中描述的婴儿HIV感染参数进行数学建模 猴口服SHIV感染和治疗模型，这反过来又可用于确定关键目标， 临床干预，以延长出生后感染婴儿的HIV-1反弹时间。这个核心与 并为该计划的所有组成部分（两个科学核心和两个项目）提供服务，并将召集 举行全方案会议，确保有效协调各项活动，从而加快进展。通过 成功完成其目标，这个核心将确保统一的研究工作和支持计划的 总体目标是确定免疫干预对病毒反弹的起源、动力学和影响， 治疗产后艾滋病毒感染。

ABSTRACT – Administrative and Statistical Core (Leader: Sallie Permar, Duke University) The objective of the Program's Administrative and Statistical Core is to provide infrastructure and oversight to ensure the Program's scientific goals are achieved and contribute a lasting impact on the field of pediatric HIV- 1 cure. The Core will be responsible for ensuring that the scientific plan is developed, implemented, and supported statistically, and will strive to reduce the administrative burden on the Program investigators. In line with these goals, the Core proposes the following Specific Aims: 1) Provide overall management, coordination, and oversight to ensure close collaboration and scientific progress; 2) Provide timely financial accounting and ensure compliance with institutional, state, and federal research guidelines; 3) Perform appropriate data management and analysis for all Projects and Cores and develop a mathematical model of factors impacting viral rebound in postnatal HIV infection. As part of Aim 3, the statistical lead will use the data generated from this Program to mathematically model the parameters of infant HIV infection depicted in the infant rhesus monkey oral SHIV infection and treatment model, which in turn can be used to identify the critical targets for clinical intervention to extend the time to HIV-1 rebound in postnatally-infected infants. This Core interacts with and serves all of the Program's components (two scientific Cores and two Projects), and will convene Program-wide meetings to ensure efficient coordination of activities, thereby accelerating progress. By successfully completing its Aims, this Core will ensure a unified research effort and support for the Program's overall goal to determine the origin, kinetics, and impact of immune interventions on viral rebound after treatment of postnatal HIV infection.