Mentoring in Sleep Research and Sleep Interventions in Heart Disease, and Stroke

 描述(申请人提供)：我的研究重点是进行旨在了解睡眠障碍的健康后果，特别是心血管后果的观察性研究，以及检验睡眠干预在改善健康方面的作用的临床试验。这个职业生涯中期导师奖的目的是：1)支持我作为睡眠医学领域以患者为中心的研究的导师的持续成长和发展；2)在我的机构的肺科、重症监护和睡眠医学部分建立以睡眠患者为中心的研究经验(孢子)指导计划；3)继续推进我自己在睡眠呼吸障碍和心血管疾病方面的研究计划。拟议的以睡眠患者为中心的研究体验计划将侧重于向受训者提供睡眠研究方法、以患者为中心的研究方法，并提供正规培训的机会，以支持日益成熟的方法。将成立一个高级咨询委员会，每6个月召开一次会议，对我的导师计划进行评估，并就未来的职业发展提出建议。该研究战略的具体目标是：1)开展联邦资助的以患者为导向的研究，并指导年轻的研究人员探索睡眠障碍和不利的心血管健康结果之间的联系，以及2)在相互作用的人类睡眠与健康的研究中开发新的方向。关于第一个目标，三个独立产生并由联邦政府资助的研究项目，其中我是PI，将提供用于实现这一目标的指导机会。这些项目包括一项长期的多中心观察性队列研究，研究多导睡眠图对不良心血管结局的预测因素，以及两项随机对照试验，研究持续气道正压(CPAP)对两个不同目标人群心血管风险标记物的影响：急性中风和充血性心力衰竭。第二个目标将由三个单独资助的CDA项目组成：一个评估睡眠呼吸暂停严重程度和ST段抬高心肌梗死之间关系的短期单中心转化性研究，一个考察ICU中昼夜节律紊乱和精神错乱之间关系的观察性队列研究，以及最后一个病例对照研究，以确定睡眠障碍呼吸障碍患者的嗜睡是否与炎症和氧化应激的遗传标记物升高有关。我对导师的承诺是我申请K24奖的主要原因。我发现，指导不同背景和水平的受训人员，他们都热衷于设计高质量的研究，以改进我们提供医疗保健的方法，这是我的职业中最有回报的方面。我要求K24涵盖我工作的25%，以便在直接指导活动和上面列出的其他目标之间相当平均地分配。我45%的努力将由额外的研究拨款支持，因此我全部努力的70%将花在与研究相关的活动上。

 DESCRIPTION (provided by applicant): My research has focused on conducting both observational studies aimed at understanding the health outcomes, particularly the cardiovascular consequences, of sleep disorders and clinical trials examining the role of sleep interventions in improving health. The objectives of this mid-career mentoring award are to 1) support my continued growth and development as a mentor in patient oriented-research in the field of sleep medicine, 2) establish a sleep patient oriented research experience (SPORE) mentoring program in the section of Pulmonary, Critical Care, and Sleep Medicine at my institution, 3) and continue to advance my own research program in sleep-disordered breathing and cardiovascular disease. The proposed Sleep Patient Oriented Research Experience (SPORE) Program will focus on providing mentees with sleep research methods, patient-oriented research methods, and opportunities for formal training to support increasing methodological sophistication. A Senior Advisory Committee will be formed and will meet every 6 months to provide an assessment my mentorship program and advise on future career development. The specific aims of the research strategy are to: 1) carry out federally funded patient-oriented research and mentor young investigators exploring the interface between sleep disorders and adverse cardiovascular health outcomes, and 2) to develop new directions in the study of the interplay human sleep and health. Regarding the first aim, three independently derived and federally funded research projects, of which I am the PI, will provide the mentorship opportunities used to accomplish this aim. These projects consist of a long- term multicenter observational cohort study examining polysomnographic predictors of adverse cardiovascular outcomes, and two randomized controlled trials examining the impact of continuous positive airway pressure (CPAP) on several domains of markers of cardiovascular risk in two separate target populations: acute stroke and congestive heart failure. The second aim will consist of 3 separate funded CDA projects: one short-term single center translational study evaluating the relationship between sleep apnea severity and ST elevation myocardial infarction, one observational cohort study examining the relationship between circadian disruption and delirium in the ICU, and, finally, one case-control study to determine whether sleepiness is associated with elevated genetic markers of inflammation and oxidative stress among patients with sleep-disordered breathing. My commitment to mentorship is the primary reason I am applying for the K24 Award. I have found that mentoring trainees of various backgrounds and levels who share a passion to design high quality studies in order to improve the methods by which we deliver health care to be the most rewarding aspect of my profession. I am requesting that the K24 cover 25% of my effort to be fairly equally divided between direct mentoring activities, and the other goals listed above. 45% of my effort will be supported by additional research grants, thus 70% of my total effort will be spent on research-related activities.