Mentoring in Sleep Research and Sleep Interventions in Heart Disease, and Stroke

心脏病和中风的睡眠研究和睡眠干预的指导

• 批准号: 10000125
• 负责人: Henry Klar Yaggi
• 金额: $ 6.47万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-06 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10000125
• 关键词: Acute; Acute Disease; Advisory Committees; Award; Behavior; Biological Markers; Cardiovascular Diseases; Cardiovascular system; Case-Control Studies; Chronic Disease; Circadian Dysregulation; Clinical Trials; Cohort Studies; Congestive Heart Failure; Continuous Positive Airway Pressure; Critical Care; Databases; Delirium; Development; Diabetes Mellitus; Disease; Drowsiness; Event; Excessive Daytime Sleepiness; Fatigue; Functional disorder; Funding; Future; Genetic Markers; Goals; Growth and Development function; Health; Health Care Costs; Healthcare; Heart Diseases; Human; Impaired cognition; Incidence; Institution; Intervention; Lung; Measures; Medicine; Mental Depression; Mentors; Mentorship; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Modeling; Myocardial Infarction; NCI Scholars Program; Observational Study; Outcome; Oxidative Stress; Patient Outcomes Assessments; Patients; Polysomnography; Prognostic Factor; Quality of life; Randomized Controlled Trials; Research; Research Methodology; Research Personnel; Research Project Grants; Retrospective Studies; Rewards; Risk Factors; Role; Severities; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep disturbances; Stroke; Supervision; Symptoms; Target Populations; Training; acute stroke; cardioprotection; cardiovascular health; cardiovascular risk factor; career; career development; cohort; design; experience; falls; improved; inflammatory marker; interest; mortality; myocardial injury; novel; patient oriented research; programs; public health relevance; sleep health; symptom management; therapy design; translational study; virtual

 DESCRIPTION (provided by applicant): My research has focused on conducting both observational studies aimed at understanding the health outcomes, particularly the cardiovascular consequences, of sleep disorders and clinical trials examining the role of sleep interventions in improving health. The objectives of this mid-career mentoring award are to 1) support my continued growth and development as a mentor in patient oriented-research in the field of sleep medicine, 2) establish a sleep patient oriented research experience (SPORE) mentoring program in the section of Pulmonary, Critical Care, and Sleep Medicine at my institution, 3) and continue to advance my own research program in sleep-disordered breathing and cardiovascular disease. The proposed Sleep Patient Oriented Research Experience (SPORE) Program will focus on providing mentees with sleep research methods, patient-oriented research methods, and opportunities for formal training to support increasing methodological sophistication. A Senior Advisory Committee will be formed and will meet every 6 months to provide an assessment my mentorship program and advise on future career development. The specific aims of the research strategy are to: 1) carry out federally funded patient-oriented research and mentor young investigators exploring the interface between sleep disorders and adverse cardiovascular health outcomes, and 2) to develop new directions in the study of the interplay human sleep and health. Regarding the first aim, three independently derived and federally funded research projects, of which I am the PI, will provide the mentorship opportunities used to accomplish this aim. These projects consist of a long- term multicenter observational cohort study examining polysomnographic predictors of adverse cardiovascular outcomes, and two randomized controlled trials examining the impact of continuous positive airway pressure (CPAP) on several domains of markers of cardiovascular risk in two separate target populations: acute stroke and congestive heart failure. The second aim will consist of 3 separate funded CDA projects: one short-term single center translational study evaluating the relationship between sleep apnea severity and ST elevation myocardial infarction, one observational cohort study examining the relationship between circadian disruption and delirium in the ICU, and, finally, one case-control study to determine whether sleepiness is associated with elevated genetic markers of inflammation and oxidative stress among patients with sleep-disordered breathing. My commitment to mentorship is the primary reason I am applying for the K24 Award. I have found that mentoring trainees of various backgrounds and levels who share a passion to design high quality studies in order to improve the methods by which we deliver health care to be the most rewarding aspect of my profession. I am requesting that the K24 cover 25% of my effort to be fairly equally divided between direct mentoring activities, and the other goals listed above. 45% of my effort will be supported by additional research grants, thus 70% of my total effort will be spent on research-related activities.



项目成果

Trajectories of Sleep Disturbance Severity in HIV-Infected and Uninfected Veterans.

• DOI: 10.1016/j.jana.2017.02.006
• 发表时间: 2017-05
• 期刊: The Journal of the Association of Nurses in AIDS Care : JANAC
• 作者: Womack JA;Murphy TE;Bathulapalli H;Akgün KM;Gibert C;Kunisaki KM;Rodriguez-Barradas M;Yaggi HK;Justice AC;Redeker NS
• 通讯作者: Redeker NS

Reducing cardiovascular risk through treatment of obstructive sleep apnea: 2 methodological approaches.

• DOI: 10.1016/j.ahj.2015.07.033
• 发表时间: 2016-02
• 期刊: American heart journal
• 影响因子: 4.8
• 作者: Yaggi HK;Mittleman MA;Bravata DM;Concato J;Ware J;Stoney CM;Redline S
• 通讯作者: Redline S

Sleep Deficiency and Opioid Use Disorder: Trajectory, Mechanisms, and Interventions.

睡眠不足和阿片类药物使用障碍：轨迹，机制和干预措施。

• DOI: 10.1016/j.ccm.2022.05.001
• 发表时间: 2022-06
• 期刊: Clinics in chest medicine
• 影响因子: 5.7
• 作者: Langstengel J;Yaggi HK
• 通讯作者: Yaggi HK

Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea.

• DOI: 10.1136/thoraxjnl-2017-210431
• 发表时间: 2018-05
• 期刊: Thorax
• 影响因子: 10
• 作者: Zinchuk AV;Jeon S;Koo BB;Yan X;Bravata DM;Qin L;Selim BJ;Strohl KP;Redeker NS;Concato J;Yaggi HK
• 通讯作者: Yaggi HK

Sleep Disturbance Among HIV-Infected and Uninfected Veterans.

感染艾滋病毒和未感染艾滋病毒的退伍军人的睡眠障碍。

• DOI: 10.1097/qai.0000000000001264
• 发表时间: 2017
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Womack,JulieA;Murphy,TerrenceE;Bathulapalli,Harini;Akgün,KathleenM;Gibert,Cynthia;Kunisaki,KenM;Rimland,David;Rodriguez-Barradas,Maria;Yaggi,HenryKlar;Justice,AmyC;Redeker,NancyS
• 通讯作者: Redeker,NancyS