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Model of mitochondrial function

Model of mitochondrial function
线粒体功能模型
批准号：
9553214
负责人：
Vipul Periwal
金额：
$13.35万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9553214
关键词：
AdenosineAffectAgonistAlzheimer&aposs DiseaseAreaAtherosclerosisBiogenesisCalciumCalcium ChannelCalcium OscillationsCellsCharacteristicsClinical ResearchCytosolDiabetes MellitusDietDiseaseEnvironmental Risk FactorEnzyme ActivationEventEvolutionFunctional disorderGenerationsGlucoseGlucose Plasma ConcentrationHigh Fat DietHomeostasisHydrogen PeroxideHydroxyl RadicalInner mitochondrial membraneInsulinInsulin ResistanceLipidsLongevityMembraneMembrane PotentialsMitochondriaModelingMyopathyObesityOrganellesParkinson DiseasePathway interactionsPhysical activityPlasmaPlayPositioning AttributePotassium ChannelProductionProteinsProton-Motive ForceReactive Oxygen SpeciesRegulationRoleSarcoplasmic ReticulumSeriesSignal TransductionSignaling ProteinSiteSourceStressStructure of beta Cell of isletSuperoxidesTherapeuticTissuesclinically relevantinsightinsulin secretionmathematical modelmitochondrial dysfunctionmitochondrial membranemitochondrial metabolismpredictive modelingvoltage

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中文摘要
翻译
我们发现，对于一系列激动剂浓度，ER-线粒体纳米结构域中的Ca 2+动力学对于维持细胞内钙振荡至关重要。该模型预测更快的Ca 2+振荡时，ER-线粒体纳米结构域和胞质溶胶之间的体积比增加。此外，鉴于三磷酸腺苷（ATP）的产生和活性氧（ROS）的产生与线粒体Ca 2+密切相关，该模型还提供了一些见解ER-线粒体纳米结构域Ca 2+动力学和线粒体功能之间的关系。我们调查，计算，减轻与异常钙动力学功能障碍的进展的策略。
英文摘要
We find that, for a range of agonist concentration, Ca2+ dynamics in ER-mitochondria nanodomains is essential for maintaining intracellular calcium oscillations. The model predicts faster Ca2+ oscillations when there is an increase in the volume ratio between ER-mitochondrial nanodomains and the cytosol. Moreover, given that the production of adenosine trisphosphate (ATP) and the generation of reactive oxygen species (ROS) are closely associated with mitochondrial Ca2+, the model also provides some insights into the relationship between ER-mitochondria nanodomains Ca2+ dynamics and mitochondrial function. We investigate, computationally, strategies for alleviating the progress of dysfunction associated with aberrant Ca2+ dynamics.
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