Frontiers in Stem Cells and Regeneration Course

描述（由申请人提供）：多能干细胞和再生医学是迅速新兴的领域，在NIH的临床，转化，生物医学和行为组合的整个范围内具有巨大的生物医学意义。这项新的R25申请寻求五年的赞助，为我们的高级培训课程，题为：前沿干细胞和再生（FrSCR）每年在MBL在伍兹霍尔根据詹妮弗摩根（MBL）和杰拉尔德Schatten（匹兹堡）的联合董事。FrSCR是从我们目前资助的U13奖项发展而来的，我们在过去几年中在伍兹霍尔成功地提供了该奖项。FrSCR建立在现有课程的显著优势和成功的基础上，同时扩展到纳入新兴的重要生物医学概念以及再生和多能性方面的复杂技术突破。本课程使参与的学员能够在多能干细胞（PSC）和再生医学领域开始成功的研究计划，包括多能成体干细胞（ASC）。我们为学员提供必要的实验室技术知识，职业指导和PSC研究的伦理法律的社会影响（ELSI），以大大提高他们成功进入这一领域。为了实现这一目标，我们提出以下具体目标：1.提供关于干细胞和再生的基本概念的深入指导。2.提供使用尖端技术进行干细胞和再生实验的详细方法的实践培训。3.教育学员在该领域的开放性问题，以及如何干细胞和再生生物学可以用来解决与人类发育和生殖障碍有关的问题。4.提供职业规划和发展的机会，并教育学员的法律的，道德和监管景观，其中再生医学研究发生。5.培养一个大学的，国际化的环境，并为学生提供网络的机会，导致长期的互动和合作。FrSCR是一个充满活力和不断发展的实体，每年都会提供一系列关于新兴概念的新的日常讲座，然后是为期一周的扩展讨论，实验室研究，技术密集的研讨会和非正式研讨会。该课程是针对既定的研究人员以及高级研究员和新的独立科学家谁致力于基础，转化或最终的临床研究。该课程解决当前的主要问题，然后进行批判性讨论和实验室实验，其中提出了先进的新技术来探索这些问题。因此，本课程将通过培训新的研究人员，为生物医学研究提供一个显着的好处 在干细胞和再生领域。

DESCRIPTION (provided by applicant): Pluripotent stem cells and regenerative medicine are rapidly emerging fields with enormous biomedical implications across the entire spectrum of NIH's clinical, translational, biomedical and behavioral portfolios. This new R25 application seeks five years of sponsorship for our advanced training course entitled: Frontiers in Stem Cells and Regeneration (FrSCR) held annually at the MBL in Woods Hole under the Co-Directorship of Jennifer Morgan (MBL) and Gerald Schatten (Pittsburgh). FrSCR developed from our currently funded U13 award, which we offered successfully at Woods Hole during the past years. FrSCR builds on the significant strengths and successes of the existing course, while expanded to incorporate emerging, important biomedical concepts and sophisticated technological breakthroughs in regeneration and pluripotency. This course enables participating trainees to start successful research programs in the fields of pluripotent stem cells (PSC) and regenerative medicine, including multipotent adult stem cells (ASC). We provide trainees the necessary knowledge of laboratory techniques, career mentoring and ethical legal societal impact (ELSI) of PSC research to greatly enhance their successful entry into this field. In order to achieve this goal, we propose the following specific aims: 1. To provide in-depth instruction on the fundamental concepts in stem cells and regeneration. 2. To provide hands-on training in the detailed methods for experimentation with stem cells and regeneration, using cutting-edge techniques. 3. To educate trainees on the open questions in the field, and how stem cells and regenerative biology can be used to solve problems related to human developmental and reproductive disorders. 4. To provide opportunities for career planning and advancement, and to educate trainees on the legal, ethical, and regulatory landscape in which regenerative medicine research occurs. 5. To foster a collegial, international environment, and to provide students with networking opportunities that lead to long-term interactions and collaborations. FrSCR is a dynamic and evolving entity that each year offers a fresh series of daily lectures on emerging concepts, followed by extended discussions, laboratory research, technologically intense workshops and informal seminars over a week-long period. The course is directed towards established investigators as well as advanced fellows and newly independent scientists who are committed to fundamental, translational or eventual clinical research studies. The course addresses major current problems, followed by critical discussions and laboratory experiments in which advanced new techniques are presented to explore these problems. Thus, this course will provide a significant benefit to biomedical research through the training of new investigators in the field of stem cells and regeneration.