Interdisciplinary Training in Quantitative Cell Biology

描述（由申请人提供）：MBL生理学课程的使命是提供细胞生理学的跨学科培训：预测和推动现代生物医学研究的发展。由于活细胞是复杂的系统，未来细胞生理学的一个关键挑战是将先进的实验技术与定量分析和计算建模相结合。为了应对这一挑战，生理学课程提供了一个独特的，跨学科的培训环境和研究计划。我们汇集了生物和物理/计算科学家，无论是作为教师还是学生，在生物医学研究前沿的未解问题上共同努力。本课程强调细胞生物学的传统主题——包括细胞运动、细胞分裂和信号传导——以及在多个尺度上解决这些问题的必要性，使用：单分子技术；体外重建；高分辨率细胞成像；以及细胞间相互作用的研究。课程的核心是一套三周两周的研究课程，强调在实践中学习，促进实验创造力和跨学科方法。实验工作伴随着计算分析和理论，以提供对所研究的生物系统和生物医学研究的现代实践的更深层次的理解。该课程的联合主任Dyche Mullins和Clare Waterman都是顶尖的细胞生物学家，有着丰富的培训记录和互补的技能。戴奇的背景是工程和数学，但他一直努力成为一名真正的细胞生物学家。克莱尔最初是一名细胞生物学家，但她目前的工作在很大程度上依赖于定量

DESCRIPTION (provided by applicant): The mission of the MBL Physiology Course is to provide interdisciplinary training in cell physiology: training that both anticipates and drives th evolution of modern biomedical research. Because living cells are complex systems, a key challenge for the future of cell physiology is to integrate advanced experimental techniques with quantitative analysis and computational modeling. To meet this challenge, the Physiology Course provides a unique, interdisciplinary training environment and research program. We bring together biological and physical/computational scientists, both as faculty members and students to work together on unanswered questions at the cutting edge of biomedical research. The course emphasizes traditional topics in cell biology -including cell motility, cell division, ad signaling -as well as the need to attack these problems at multiple size scales, using: single-molecule techniques; in vitro reconstitutions; high-resolution cell imaging; and studies of cell-cel interaction. The heart of the course is a set of three, 2-week research sessions that emphasize learning by practice and promote experimental creativity and interdisciplinary approaches. Experimental work is accompanied by computational analysis and theory to provide a deeper understanding of both the biological systems being studied and the modern practice of biomedical research. The co-directors of the course, Dyche Mullins and Clare Waterman are leading cell biologists with strong training records and complementary skills. Dyche's background is in engineering and mathematics but he has worked hard to become a bona fide cell biologist. Clare began as a cell biologist but her current work relies heavily on quantitative and computational approaches and is influenced by soft condensed matter physics. Both are alumni of the 1993 Physiology Course and both served for years as faculty members in the course before taking it over. They have assembled an outstanding faculty, with backgrounds in cellular physiology, physics, engineering and computational science. In addition, the co-directors have recruited a set of distinguished visiting scholars and members of the MBL scientific community to provide additional training. We strive to make this course a widely recognized venue for interdisciplinary training, one where experimental, computational, and theoretical scientists gather to share their philosophies and approaches. We request continued support for this exciting endeavor. The current application is for a competitive renewal of an award originally funded under the NIH Roadmap Initiative and then renewed under the R13 mechanism.