Development of Novel MR Imaging for Ischemic Stroke Evaluation

摘要 这项研究的广泛、长期目标是改善缺血性卒中的诊断和治疗。在这 建议的工作，我们将开发新的生物医学成像技术的基础上MRI。根据最近的核磁共振成像 基于成功使用MRI进行卒中分诊的成像试验， 相位生理和血管造影成像。在本提案中，我们将开发、验证和执行 首次能够对体积变化进行成像的新MRI脉冲序列的初步研究 在脑灌注、桶侧支流和组织氧合中的作用。本课题组 汇集了两个顶级研究机构，使用 缺血性中风的新动物模型。该模型的使用将允许软脑膜侧支的直接可视化 血流、脑生理学的局部改变和对血流增强治疗的假设反应。

Abstract The broad, long term goal of this research is to improve the diagnosis and treatment of ischemic stroke. In this proposed work we will develop new biomedical imaging technologies based on MRI. In light of recent MRI based imaging trials which successfully use MRI for stroke triage, there is an unmet need to improve acute phase physiologic and angiographic imaging in stroke. In this proposal we will develop, validate and perform a pilot study of new MRI pulse sequences that are capable, for the first time, the imaging of volumetric changes in cerebral perfusion, pail collateral flow, and tissue oxygenation in under 10 minutes. Our research group brings together two top-tier research institutes to interactively alter and image cerebral physiology using a novel animal model of ischemic stroke. The use of this model will allow direct visualization of the pial collateral flow, local alteration in cerebral physiology and the hypothesized response to flow augmentation therapy.