Neuromotor Mechanisms and Rehabilitation

7.项目摘要--资源核心3 神经运动机制和康复(核磁共振)核心(资源核心-3)的中心假设是 适当选择活动和以锻炼为基础的康复干预措施可以促进有益的 大脑((中枢神经系统)结构、连通性和生理学)和神经运动的变化 在慢性疾病中改善运动性能和功能并将残疾降至最低的机制 影响老年人。资源核心-3(RC-3)为UM-OAIC提供支持、指导和指导 使用多系统方法的研究人员侧重于全身平衡、活动和上肢活动 解决建立新的康复策略以改善运动功能的机械基础 并促进患有慢性疾病相关残疾的老年人的康复。穿过 这一框架、功能活动和运动介导的脑和神经运动可塑性可以被识别为 指导针对具体情况和个人的康复方法，以最大限度地减少残疾。这个 RC-3和RC-2之间的互补和协作关系侧重于肌肉、代谢和 衰老与残疾的心血管机制，锻造强大而全面的核心间协同作用 了解设计和测试有效的新康复计划的多系统基础。RC-3 在研究工作组中跨UM-OAIC核心进行协作，以培训和开发下一代 研究人员和康复干预将提高老年慢性阻塞性肺疾病患者的运动功能 残疾。使用方法论工具箱，它对全身姿势和平衡进行定量测试， 活动性、上肢活动和脑和神经运动过程的功能任务 控制和可塑性潜在的功能活动和运动衍生的运动表现和收益 在UM-OAIC干预措施中发挥作用。 RC-3将继续支持、增强和开发正在进行的和新的项目，这些项目将定义 中枢神经系统和外周都有慢性致残衰老的情况，并制定有效的康复方案 加强运动功能和预防慢性残疾的计划。

7. Project Summary- Resource Core 3 The central hypothesis of the Neuromotor Mechanisms and Rehabilitation (NMR) Core (Resource Core-3) is that appropriately-selected activity and exercise-based rehabilitation interventions can promote beneficial changes in brain ((central nervous system (CNS) structure, connectivity, and physiology)) and neuromotor mechanisms to improve motor performance and function and minimize disability in chronic medical conditions affecting older people. Resource Core-3 (RC-3) provides support, guidance, and mentoring to UM-OAIC investigators using a multi-system approach focused on whole-body balance, mobility, and upper limb activities to address the mechanistic bases upon which to build novel rehabilitation strategies to improve motor function and independence and promote recovery in older people with chronic disease-associated disabilities. Through this framework, functional activity and exercise-mediated brain and neuromotor plasticity can be identified to guide condition-specific and individual-specific rehabilitation approaches for minimizing disability. The complementary and collaborative relationship between RC-3 and RC-2 focusing on muscle, metabolic, and cardiovascular mechanisms of aging with disability, forges a strong and comprehensive inter-core synergy for understanding the multi-system bases for designing and testing effective new rehabilitation programs. RC-3 collaborates across UM-OAIC cores in research working groups to train and develop the next generation of investigators and rehabilitation interventions that will enhance motor function in older adults with chronic disability. Using a toolbox of methodologies, it performs quantitative tests of whole-body posture and balance, mobility, upper limb activities, and functional tasks that characterize the processes of brain and neuromotor control and plasticity underlying functional activity and exercise derived gains in motor performance and function across UM-OAIC interventions. RC-3 will continue to support, augment, and develop ongoing and new projects that will define the changes in both the CNS and the periphery with chronic disabling conditions of aging, and devise effective rehabilitation programs to enhance motor function and prevent chronic disability.