UAB Predoctoral Training Grant in Translational and Molecular Sciences

 描述(由申请人提供)：这是阿拉巴马大学伯明翰分校(UAB)翻译和分子科学(TMS)新的博士前培训补助金申请。目前，很少有博士毕业生进入劳动力大军，他们拥有足够的疾病病理生物学培训和翻译经验，无法有效地将分子进步转化为临床实践。这项建议满足了这一需求，我们的目标是提供一个培训环境，为下一代博士生物医学科学家提供必要的技能，将翻译目标纳入他们的研究，并为未来的劳动力做好准备。我们最近在研究生教育方面的经验表明，学生对翻译研究培训的需求不断增加，这是目前申请翻译研究的驱动力。对博士前学生进行有效的翻译科学培训的一个主要挑战是需要纳入多个学科和概念，从了解疾病机制，了解如何在学术界或行业中翻译研究结果，到了解监管程序和规则。我们建议一个两年制的项目(每年招收6名学生)，学生在二年级开始时入学。提出了一种综合课程，涉及教学要素(包括了解疾病机制、药物发现和开发、翻译研究管理)、职业和翻译研究丰富活动(包括参加 翻译和分子科学证书课程、学术和行业研讨会、CTSA互动、著名演讲者系列)以及有意义的临床/患者互动体验，后者将与学员的研究兴趣联系起来。我们觉得 在学生入学初期为学生提供翻译研究方面的培训将提供所需的技能，并使他们能够在智力上将翻译研究纳入他们的研究，并为他们为未来劳动力的多样化需求做好准备。为了实现这一目标，我们召集了42名培训人员，他们拥有资金雄厚的实验室和独特的专业知识(45%的博士，45%的医学博士，10%的医学博士)和经验，他们的集体研究解决了基本的科学问题，重点是翻译和人类疾病。该计划的另一个目标是让更多的医学博士参与研究生培训和教育。几个疾病领域是UAB的长期优势，并与临床和基础科学系以及UAB中心整合在一起，将为不同研究学科的学生提供广度。这项建议强调了我们以前和现在对博士前教育的承诺，以及我们的共同目标，即为学生提供一个学习和发展他们在生物医学研究和其他科学相关职业中取得成功所需的技能的环境。

 DESCRIPTION (provided by applicant): This is a new pre-doctoral training grant application in Translational and Molecular Sciences (TMS) at the University of Alabama at Birmingham (UAB). Currently, too few PhD graduates are entering the workforce with sufficient training in pathobiology of disease and translational experiences to effectively translate molecular advances into clinical practice. This proposal addresses this need with our goal being to provide a training environment that provides the necessary skills for the next generation of PhD biomedical scientists to incorporate translational objectives into their research and prepare them for the workforce of tomorrow. Our recent experiences in graduate education show increased demand from students for training in translational research; this is the driving force behind the current application. A major challenge in effective training in translational sciences for pre-doctoral students is the need to incorporate multiple disciplines and concepts ranging from understanding disease mechanisms, understanding of how findings may be translated in academia or industry, to understanding regulatory oversight procedures and rules. We propose a 2 year program (with 6 students per year) with students enrolling at the beginning of their second year. An integrative curriculum is proposed that involves didactic elements (that includes understanding disease mechanisms, drug discovery and development, translational research administration), career and translational research enrichment activities (including enrollment in a Certificate program in Translational and Molecular Sciences, academia and industry workshops, CTSA interactions, Eminent Speaker Series) and meaningful clinical / patient interaction experiences, the latter of which will be linked with the trainees' research interests. We feel that providing students with training in translational research early during a student's matriculation will provide required skills and empower them intellectually to incorporate translational research into their research and prepare them for the diverse requirements for the future workforce. To achieve this, we have assembled 42 training faculty with well-funded laboratories and a unique array of expertise (45% PhD, 45% MD, and 10% MD PhD) and experience whose collective research addresses fundamental scientific problems with a strong emphasis on translation and human disease. An additional goal of this program will be to involve more MDs in graduate training and education. Several disease areas that are perennial strengths of UAB and integrated with clinical and basic science departments, together with UAB Centers are represented and will provide breadth for students in diverse research disciplines. This proposal underscores our previous and ongoing commitment to pre-doctoral education and our collective goal of providing an environment for students to learn and develop the skills they will require to be successful in the biomedical research and other science related occupations.