FASEB SRC on Calcium and Cell Function

 描述(申请人提供)：钙是一种普遍的生物信号分子，几乎被所有形式的生命所使用，从植物、微生物、动物到人类。它是细胞功能不可缺少的，在心血管、神经和免疫系统以及许多其他器官中发挥着重要作用。钙信号对人类疾病的重要性怎么强调都不为过。随着对钙通道、泵、转运体和结合蛋白生理学的基础科学发现，人们对异常钙信号在许多疾病中的病理生理作用有了新的见解。这些疾病包括自身免疫、胰腺炎、阿尔茨海默病、神经精神疾病、心律失常等常见疾病，以及更罕见的遗传性疾病，如严重的联合免疫缺陷，这些疾病为特定钙处理分子的功能提供了关键的洞察力。对钙信号分子调控的新见解导致了对治疗自身免疫、炎症、高血压、心力衰竭、神经和其他疾病的可行新药靶点的确定，新药正在开发、临床试验或已在使用中。此申请是为2016年6月12-17日在葡萄牙里斯本举行的2016年FASE B关于钙和细胞功能的科学研究会议(SRC)提供部分资金支持。这是一系列两年一度的会议中的第15次。这将是2016年钙领域最重要的国际会议， 一个论坛，来自世界各地的顶尖科学家聚集在一起，介绍和讨论他们最新和最重要的研究。会议的目的是促进对钙信号和动态平衡的分子和细胞机制的理解，并阐明钙在健康和疾病中的生理和病理作用。本次会议的重点将放在钙信号异常在免疫紊乱的发病机制中的作用，特别是感染性、炎症性和过敏性疾病。除了这些具体的科学目标外，会议还寻求通过召集国际公认的专家来促进当前钙领域前沿科学知识和思想的自由交流。重要的是，这次会议旨在为青年科学家提供机会，在非正式的环境中介绍他们的工作，并在他们之间和该领域的领导人之间进行严格的科学讨论，并通过有组织的专家见面会为青年科学家提供职业咨询。为了实现这些目标，120-140名资深研究人员和年轻科学家将在会议期间通过长时间和短时间的演讲、海报和非正式讨论来讨论尖端研究。组织者将尽一切努力忠实地代表该领域的多样性，并为妇女、未被充分代表的少数民族和初级科学家提供展示其工作的机会。

 DESCRIPTION (provided by applicant): Calcium is a universal biological signaling molecule that is used by nearly all forms of life, from plants, microbes, animals to humans. It is indispensable for cell function and plays an important role in the cardiovascular, nervous and immune systems as well as many other organs. The significance of calcium signaling for human disease cannot be overstated. Basic science discovery into the physiology of calcium channels, pumps, transporters and binding proteins has been accompanied by new insights into the pathophysiological role of abnormal calcium signals in numerous diseases. These include common conditions like autoimmunity, pancreatitis, Alzheimer's disease, neuropsychiatric diseases, cardiac arrhythmias, and also more rare genetic disorders such as severe combined immunodeficiency, that have provided critical insight into the function of specific calcium handling molecules. New insights into the molecular regulation of calcium signals have led to the identification of viable new drug targets for the treatment of autoimmunity, inflammation, hypertension, heart failure, neurological and other disorders with new drugs being in development, clinical trials or already in use. This application is for partial financial support o the 2016 FASEB Science Research Conference (SRC) on Calcium and Cell Function, which will be held from June 12 - 17, 2016 in Lisbon, Portugal. This is the 15th in a series of biennial conferences. It will be the most significant international meeting of the calcium field in 2016 and a forum where leading scientists from around the world come together to present and discuss their latest and most important research. The objectives of the conference are to facilitate the understanding of the molecular and cellular mechanisms of calcium signaling and homeostasis, and to elucidate the physiological and pathological effects of calcium in health and disease. Emphasis at this meeting will be placed on the role of aberrant calcium signals in the pathogenesis of immunological disorders, especially infectious, inflammatory and allergic diseases. Besides these specific scientific objectives, the meeting seeks to foster the free exchange of current scientific knowledge and ideas at the forefront of the calcium field by bringing together internationally recognized experts. Importantly, the conference aims to provide young scientists with the opportunity to present their work and to engage in rigorous scientific discussion among themselves and with leaders in the field in a casual environment, and to provide career counseling to young scientists through organized Meet-the-Experts sessions. To accomplish these objectives, 120-140 established investigators and young scientists will discuss state-of the art research in long and short talks, posters and informal discussions during the meeting. The organizers will make every effort to faithfully represent the diversity of the field ad provide women, underrepresented minorities and junior scientists with the opportunity to present their work.