Genomics

人类基因组测序给癌症研究带来了革命性的变化。基因组学核心是一个 机构共享资源，由科赫研究所和其他三个麻省理工学院单位共享，提供 中心成员在全基因组分析方面提供综合和全面的服务。在前一段时间里， 该核心(以前称为微阵列技术核心)专门专注于基于微阵列的 技术。作为核心重组计划的一部分，这个共享的基因组核心的使命是 在本期内大幅扩张。首先，核心承担起提供我们所有下一个 世代测序能力(以前由生物聚合物和蛋白质组学核心提供)。第二，它 最近建立了专注于肿瘤学的高通量小分子和shRNA筛选能力，具有 CCSG发展基金和麻省理工学院基金的支持。核心还获得了新的仪器和一个 增加了工作人员，以支持这两项活动。在本期间，超过80%的用户使用核心 该中心成员，包括来自所有四个项目的调查人员。因此，这种共享资源是必不可少的 为科赫研究所任务的成功干杯。在接下来的一段时间里，这个核心将继续提供广泛的 一系列最先进的全基因组技术，支持科赫研究所的癌症研究任务。 值得注意的是，中心成员占核心服务总使用量的55%，但请求的CCSG 预算不到利益攸关方捐款总额的50%。

The sequencing of the human genome has revolutionized cancer research. The Genomics Core is an Institutional Shared Resource, shared between the Koch Institute and three other MIT units, which provides Center Members with integrated and comprehensive services in genome-wide analyses. In the prior period, this Core (previously named the Microarray Technologies Core) focused specifically on microarray-based technologies. As part of a core-wide reorganization plan, the mission of this shared Genomics Core was greatly expanded in the current period. First, the Core took on the responsibility for providing all of our next generation sequencing capabilities (previously offered by the Biopolymers & Proteomics Core). Second, it recently established oncology-focused, high throughput small molecule and shRNA screening capabilities, with support from CCSG developmental and MIT funds. The Core also acquired new instrumentation and an expanded staff to support both of these activities. In the current period, the Core is used by more than 80% of the Center Members, including investigators from all four Programs. Thus, this Shared Resource is essential to the success of the Koch Institute mission. In the upcoming period, this Core will continue to offer a wide range of state-of-the-art genome-wide technologies to support the Koch Institute’s cancer research mission. Notably, Center Members represent 55% of the total usage of the Cores services, but the requested CCSG budget is less than 50% of the total stakeholder contributions.