Core B: Neuroscience Core

摘要/摘要 当前课程的目标是促进我们对分子和神经回路的理解。 大脑中控制心血管功能和能量代谢的机制。神经科学 CORE旨在为研究影响神经机制提供关键设备和技术支持 心血管和新陈代谢功能将由该计划内的所有四个项目使用。 调查人员将通过这一核心完全访问一系列设备，以实现拟议的目标 涉及大脑区域特异性基因操作、化学发生方法、多纤维记录的研究 局部交感神经活动和脑组织学检查。此外，董事及 核心工作人员将为所有项目提供所有必要的外科支持和培训。这些资源的集中化 端点进入核心将确保所有提议的实验的科学严密性和重复性，这些实验将使用 整个项目都有先进的神经科学技术。

Summary / Abstract The objective of the current program is to advance our understanding of the molecular and neurocircuitry mechanisms within the brain that control cardiovascular function and energy metabolism. The Neuroscience Core is designed to provide critical equipment and technical support for studying neural mechanisms affecting cardiovascular and metabolic functions that will be employed by all four projects within the program. Investigators will have a full access to an array of equipment through this core to achieve the goal of proposed studies that involve brain-region-specific gene manipulation, chemogenetic approach, multi-fiber recording of regional sympathetic nerve activity, and histological examination of the brain. In addition, the Directors and core staff will provide all necessary surgical support and training for all projects. The centralization of these endpoints into a core will ensure scientific rigor and reproducibility of all proposed experiments that will use advanced neuroscience techniques across the program.