Rural Comorbidity and HIV consequences of Opioid use Research and Treatment Initiative (Rural cohort)

农村科摩罗和阿片类药物使用对艾滋病毒的影响研究和治疗倡议的目的 （农村队列）协调中心（CC）负责协调和支持NIH资助的队列合作 研究，因为他们进行评估和实施循证实践，以解决阿片类药物使用，艾滋病毒和 农村社区的相关并发症。总体目标是改善整体健康状况， 这些弱势群体的后果。还有机会增加艾滋病毒预防的使用， 以可能降低艾滋病毒发病率和预防新的艾滋病毒的方式解决阿片类药物的使用问题 吸毒者中的流行病。实现这些目标将需要一个有数据经验的CC 协调、多地点协调和研究药物使用干预措施及其对 有和没有艾滋病毒的药物使用人群，全面整合临床研究数据， 多项研究。从多项研究中全面整合临床数据的大型资源 将使研究人员有可能解决重要的科学和公共卫生问题， 药物使用和艾滋病毒预防以及注射毒品者（PWID）的结果， 可以进行更小的研究。作为农村队列CC，我们将与研究中心合作， 使用来自不同人群的统一数据对许多不同人群的结局和结果进行完整分析 网站.这将提高统计能力，以确定研究重点的领域或分组， 了解哪些干预措施在更广泛的农村人口中证明是成功的， PWID（与单一成员研究中心的目标人群相反）。将认真协调数据， 与直观的交付工具相结合，以确保这些高质量的数据可广泛提供给会员 网站.农村队列CC团队在数据链接和协调方面拥有丰富的经验， 发展、观测研究的统计支持、平台和工具开发， 有效和准确地收集患者报告的结局和结局裁定， 协调队列和研究的大型合作，以及强大的临床流行病学背景 艾滋病和药物使用。这将使我们能够协助研究改进和加强数据收集 在可行的情况下，酌情合并和统一数据，并更密切地合作， 关于药物使用、艾滋病毒和农村环境中无法由个人解决的结果的关键问题 问题研究

The purpose of the Rural Comorbidity and HIV consequences of Opioid use Research and Treatment Initiative (Rural Cohort) Coordinating Center (CC) is to coordinate and support a cohort collaboration of NIH funded studies as they conduct assessments and implement evidence-based practices to address opioid use, HIV and related comorbidities in their rural communities. The overarching purpose is to improve the overall health and outcomes of this vulnerable population. There is also an opportunity to increase the use of HIV prevention and care services and address opioid use in ways that are likely to reduce HIV incidence and prevent new HIV epidemics among substance users. Achieving these objectives will require a CC experienced in data harmonization, multi-site coordination, and research on substance use interventions and impact among substance using populations with and without HIV to comprehensively integrate clinical research data from multiple studies. The resulting large resource of comprehensively integrated clinical data from multiple studies will give researchers the potential to address important scientific and public health questions related to substance use and HIV prevention and outcomes among persons who inject drugs (PWID) that would not be possible with smaller studies. As the Rural Cohort CC, we will work with sites to allow complex, careful, and complete analysis of outcomes and results over many diverse populations using harmonized data from across sites. This will improve the statistical power to identify areas or sub-groups for research focus and to understand what interventions are proving successful in the broader context of the whole population of rural PWID (as opposed to in the target population of a single member site). Careful data harmonization will be paired with intuitive delivery tools to ensure that this high-quality data is made widely available to the member sites. The Rural Cohort CC team brings vast experience with data linkage and harmonization, methods development, statistical support for observational research, platform and tool development such as for the efficient and accurate collection of patient reported outcomes and outcomes adjudication, providing overall coordination for large collaborations of cohorts and studies, and a strong background in clinical epidemiology of HIV and substance use. This will allow us to assist the studies to improve and enhance data collection where appropriate, merge and harmonize data when feasible, and work together more closely to address the key questions on substance use, HIV, and outcomes in rural settings that cannot be addressed by individual studies.