Administrative Core

行政核心 项目摘要/摘要 MSKCC-Cornell癌症纳米医学翻译中心（MC 2 TCN）将建立一个环境， 为加强基础材料的一体化研究，对特定类别的超小型（直径<10纳米） 纳米颗粒在肿瘤学领域的转化努力。为了实现这一目标，我们提出了一个 中心内的综合管理核心。这个核心将是多学科中心的来源 领导，并将管理中心的行政努力，以精简发展的高度 集成了新型粒子结构和几何形状，以改进用于癌症诊断的术中工具， 分期，以及增强放射治疗和药物递送产品的功效。这将需要 开发和/或鉴定新的表征方法，基因工程动物模型， 成像分析工具和定量组织学程序。我们建议的领导和管理 结构确保该中心的调查人员和其他研究人员在康奈尔大学，MSKCC，和大学 密苏里州将有机会获得基础设施，人员和专业知识，可用于促进这些 将这些纳米颗粒产品转化为临床及其后续应用的必要发展 商业化我们提出了一个将弥合现有差距的领导和管理结构 在基础和临床研究人员之间，确保中心的所有研究人员都能充分利用 现有的和拟议的机构间资源，用于癌症纳米技术的应用。通过 为实现本节提出的目标，行政核心将领导中心 并将简化行政工作，以加速临床可翻译的纳米颗粒的开发 产品.

ADMINISTRATIVE CORE Project Abstract/Summary The MSKCC-Cornell Center for Translation of Cancer Nanomedicines (MC2TCN) will establish an environment for the enhanced integration of basic materials research on specific classes of ultrasmall (<10 nm diameter) nanoparticles with translational efforts in the field of oncology. In order to achieve this goal we propose a comprehensive Administration Core within the Center. This core will be the source of multidisciplinary Center leadership, and will manage the Center's administrative efforts to streamline the development of highly integrated novel particle architectures and geometries to improve intraoperative tools for cancer diagnosis and staging, as well as to enhance the efficacy of radiotherapeutic and drug delivery products. This will require the development and/or identification of new characterization methods, genetically engineered animal models, imaging analysis tools, and quantitative histological procedures. Our proposed leadership and management structure ensures that the Center's investigators and other researchers at Cornell, MSKCC, and University of Missouri will have access to infrastructure, personnel, and expertise that can be used to facilitate these necessary developments for translation of these nanoparticle products into the clinic and their subsequent commercialization. We have proposed a leadership and management structure that will bridge existing gaps between basic and clinical researchers, ensuring that all of the Center's investigators can take full advantage of both the existing and proposed inter-institutional resources for cancer nanotechnology applications. By accomplishing the Aims proposed in this section, the Administrative Core will provide leadership to the Center and will streamline administrative efforts to accelerate the development of clinically translatable nanoparticle products.