The Impact of Gestational and Postnatal Triclosan Exposure on Eczema, Wheeze, and Asthma Risk in Children

项目总结 我是一名环境流行病学家，主要研究早期生命化学物质的作用。 暴露在免疫系统和呼吸系统上。这项提议的目标是获得所需的技能 进一步我的博士后培训，检查早期生活中的化学品暴露和儿童过敏，呼吸道，和 免疫结果。将化学物质暴露和过敏性疾病的发展联系起来对于改善我们的 了解儿童特应性疾病的可改变的危险因素，包括湿疹和哮喘。正式 约瑟夫·布劳恩博士、亚当·斯潘尼尔博士和乔治·帕潘多纳托斯博士的课程和专家指导将 使我能够获得知识、技能和能力，以实现我成为一名 独立研究人员。这项培训将使我能够追求独立研究的目标，以检查影响 三氯生暴露对喘息、湿疹和哮喘风险的影响 一个持续的队列。所有相关的暴露、协变量和结果都是先前收集的NIH- 资助的健康结果和环境措施(家庭)研究，一项正在进行的怀孕和分娩 队列研究。这项提案的主要目标是严格描述与妊娠相关的 以及儿童早期接触三氯生并伴有湿疹和哮喘的结果，以确定潜在的 暴露于三氯生的过敏和/或呼吸道健康易感性窗口。具体地说，我会在 孕期和儿童期接触三氯生的生物标志物和先进的流行病学测量方法 他们对布劳恩博士的影响，2)向帕潘多纳托斯博士和布劳恩博士学习高级统计技能：a) 纵向和重复测量分析以表征湿疹和喘息的模式和轨迹， B)确定易受影响的窗口，以增强我们检测影响的能力；c)确定易受影响的群体， 3)关于儿童早期过敏发展、呼吸道炎症和儿童肺部发育的培训 与斯潘尼尔博士一起学习生理学，并将我的研究和培训转化为未来的K奖。 这项建议将解决对三氯生暴露可能影响的时间的理解上的差距。 儿童过敏性疾病的发展。这项建议的研究和培训计划为我的 独立研究生涯，旨在阐明早期接触环境化学品可能会有多大程度的影响 哮喘和其他过敏性疾病发生的重要决定因素及其潜在的生物学意义 他们可能采取行动的机制。

PROJECT SUMMARY I am an environmental epidemiologist with primary research interests in the role of early-life chemical exposures on the immune and respiratory systems. The goal of this proposal is to obtain skills needed to further my postdoctoral training in examining early-life chemical exposures and child allergic, respiratory, and immune outcomes. Linking chemical exposures and allergic disease development is important to improve our understanding of modifiable risk factors for childhood atopic diseases, including eczema and asthma. Formal coursework and expert mentorship from Drs. Joseph Braun, Adam Spanier, and George Papandonatos will enable me to acquire the knowledge, skills, and abilities to achieve my long-term career goal of becoming an independent researcher. This training will allow me to pursue independent research aims examining the impact of triclosan exposures on wheeze, eczema, and asthma risks using longitudinal exposure and outcome data in an ongoing cohort. All relevant exposure, covariate, and outcome were previously collected as part of the NIH- funded Health Outcomes and Measures of the Environment (HOME) Study, an ongoing pregnancy and birth cohort study. The primary objectives of this proposal are to rigorously characterize associations of gestational and early-childhood exposure to triclosan with eczema and asthma outcomes in order to identify potential windows of allergic and/or respiratory health susceptibility from triclosan exposure. Specifically, I will 1) train in biomarkers of gestational and childhood triclosan exposure and advanced epidemiologic methods to measure their impacts with Dr. Braun, 2) learn advanced statistical skills with Drs. Papandonatos and Braun: a) in longitudinal and repeated measures analyses to characterize patterns and trajectories of eczema and wheeze, b) to identify susceptible windows to enhance our ability to detect effects and c) to identify vulnerable groups, 3) train in early-childhood allergy development, airway inflammation, and child lung development and physiology with Dr. Spanier, and 4) translate my research and training to position myself for a future K-award. This proposal will address gaps in the understanding of the timing through which triclosan exposure may affect allergic disease development in children. This proposed research and training plan lays the foundation for my independent research career that aims to clarify how early-life exposures to environmental chemicals may be important determinants of asthma and other allergic disease development and the potential biological mechanisms through which they may act.