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中文摘要
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项目摘要 本申请寻求对戈登研究会议(GRC)的支持,该会议的主题是“ALS及相关电机 神经元疾病“,将于2019年7月21日至26日在佛蒙特州西多佛市的雪山举行。这一秒 两年一次的会议汇集了高级和初级科学家和临床医生,他们进行了临床研究 肌萎缩侧索硬化症及相关运动神经元病的检查和治疗 包括脊髓性肌萎缩症(SBMA)和脊髓性肌萎缩症(SMA),进行性 肌萎缩症(PMA)和多系统蛋白病(MSP)。GRC将由戈登陪同 研究研讨会(GRS),于2019年7月20日至21日在同一地点举行,并具体 以上述研究界的学生和博士后研究员为目标,并由他们组织。 GRC将分为九个科学会议和每日海报演示。国内和国际 将邀请该领域的专家作为演讲者,介绍未发表的研究成果。此外,我们还将给予 选定的海报摘要作者,通常是年轻的调查人员或实习生,有机会介绍 在这些专家中。GRC为具有跨学科专业知识的科学家提供了一个独特的机会 交流想法和假设,从而为寻找新的治疗方法而进行新的合作努力 针对受这些疾病影响的患者的目标和治疗。
英文摘要
Project Summary This application seeks support for the Gordon Research Conference (GRC) on “ALS and Related Motor Neuron Diseases,” which will take place from July 21-26th, 2019 at Mount Snow, West Dover, VT. This second biennial meeting brings together both senior and junior scientists and clinicians who investigate, clinically examine and therapeutically treat Amyotrophic Lateral Sclerosis (ALS) and related motor neurons diseases including spinal-bulbar muscular atrophy (SBMA), as well as spinal muscular atrophy (SMA), progressive muscular atrophy (PMA) and multisystem proteinopathy (MSP). The GRC will be accompanied by a Gordon Research Seminar (GRS), which takes place July 20-21st, 2019 at the same location, and is specifically targeted at and organized by students and postdoctoral fellows of the aforementioned research community. The GRC will be divided into nine scientific sessions and daily poster presentations. National and international experts of the field will be invited as speakers to present unpublished research. In addition, we will give selected poster abstract authors, which are generally young investigators or trainees, an opportunity to present among these experts. This GRC provides a unique opportunity for scientists of interdisciplinary expertise to exchange ideas and hypotheses that will lead to new collaborative efforts towards finding new therapeutic targets and treatments for patients affected by these diseases.
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Mechanisms of A-I RNA editing-mediated nuclear export of TDP-43
Microglia contribution to disease pathogenesis in C9orf72 ALS/FTD
Microglia contribution to disease pathogenesis in C9orf72 ALS/FTD
Astrocyte regulation of cortical neurodegeneration in C9orf72 FTD/ALS
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