Southern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT)

我们建议建立南部新英格兰中风研究、创新和治疗伙伴关系（SPIRIT）， StrokeNet区域协调中心（RCC）由3个领先机构组成：耶鲁大学医学院， 布朗大学沃伦阿尔珀特医学院和哈特福德医院。每个枢纽都是一个综合性的 中风中心共有14个主要中风中心。耶鲁是美国第七大医院， 与布朗和哈特福德医院及其各自的网络合作，SPIRIT捕获了多样化的 地理区域，为570万人提供服务，包括大多数成人和儿童中风患者， 康涅狄格和罗得岛。这一强劲的患者数量（2016年总计超过3500例卒中患者）， 凭借非常强大的协作和组织框架，SPIRIT在临床应用方面具有巨大的潜力。 试行。首席研究员Kevin N. Sheth（耶鲁大学），Karen Furie博士（布朗大学）和Mark博士 Alberts（哈特福德医院）带来了一套互补的领导和高水平的临床试验经验， 中风每位领导人都带来了国际多中心研究和实施 中风护理系统，以及高质量中风试验招募和保留的跟踪记录。以各种 能力，他们一起工作了12年以上，每个PI领导一个热情的教师干部 跨学科，创造一个高度协作的环境，专注于中风研究，多中心试验， 机构审查委员会、临床试验委员会的成员资格，以及以患者为导向的广泛指导 research. SPIRIT与NIH资助的CTSA网络保持着密切的联系，并通过以下方式进一步加强： 具有以下特点：1）拥有一批具有全国公认的临床和 中风转化研究专业知识; 2）患者的多样性（包括种族/种族以及城市/农村） 在新英格兰南部，目前没有被现有的StrokeNet网络捕获; 3）积极的领导和 参与卒中社区和卒中护理系统的全州政策，护理的连续性， 美国心脏协会合作和区域教育; 4）为所有人提供深入的研究者和患者库 中风网络倡议的三个领域--预防、急性治疗和恢复; 5）获得一系列 各中心之间已经统一的专用工具，包括通用电子病历系统 （EPIC）和RAPID软件用于急性卒中成像，加强数据共享和协作; 6）持续 所有三家机构都承诺采用中心IRB模式并使用主试验协议; 7）Rich 科学核心与正在进行的NIH资助的中风研究和多个，目前正在积极的StrokeNet提案 8）一个旨在识别、支持和加速未来发展的教育核心 中风研究者耶鲁大学、布朗大学和哈特福德中风队在一起--合作的总和 比每一部分都更令人兴奋-准备为加强和进一步发展 NINDS和StrokeNet的使命是减轻神经系统疾病的负担。

We propose the Southern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT), a StrokeNet Regional Coordinating Center (RCC) anchored by 3 leading institutions: Yale School of Medicine, the Warren Alpert School of Medicine at Brown University, and Hartford Hospital. Each Hub is a Comprehensive Stroke Center with 14 total Primary Stroke Centers. Yale is the 7th largest hospital in the United States, and in collaboration with Brown and Hartford Hospital, and their respective networks, SPIRIT captures a diverse geographic area that provides access to 5.7 million people, including most adult and pediatric stroke patients in Connecticut and Rhode Island. This robust patient volume (over 3500 total stroke patients in 2016), combined with an exceptionally strong collaborative and organizational framework, gives SPIRIT great potential for clinical trial implementation. Principal Investigators Dr. Kevin N. Sheth (Yale), Dr. Karen Furie (Brown), and Dr. Mark Alberts (Hartford Hospital) bring a complementary set of leadership and high-level clinical trials experience in stroke. Each leader brings well recognized expertise in international multicenter studies and implementation of stroke systems of care, as well as a track record of high quality stroke trial recruitment and retention. In various capacities, they have worked together for over 12 years, and each PI leads an enthusiastic cadre of faculty across disciplines, to create a highly collaborative environment focused on stroke research, multicenter trials, membership on Institutional Review Boards, clinical trial committees, and extensive mentoring in patient-oriented research. SPIRIT maintains strong connections to NIH funded CTSA networks and is further strengthened by the following characteristics: 1) A pool of talented investigators with nationally recognized clinical and translational research expertise in stroke; 2) Rich diversity (both ethnic/racial as well as urban/rural) of patients in Southern New England currently not captured by the existing StrokeNet network; 3) Active leadership and participation in stroke communities and stroke systems of care in the areas of statewide policy, continuity of care, American Heart Association collaborations and regional education; 4) Deep investigator and patient pools for all three areas of StrokeNet initiatives – prevention, acute treatment, and recovery; 5) Access to a range of specialized tools already harmonized across centers including a common electronic medical record system (EPIC) and RAPID software for acute stroke imaging, enhancing data sharing and collaboration; 6) Continuous commitment from all three institutions to the central IRB model and use of a Master Trial Agreement; 7) Rich science core with ongoing NIH funded stroke studies and multiple, active StrokeNet proposals currently under review; and 8) An education core designed to identify, support and accelerate the development of tomorrow's stroke investigators. The Yale, Brown, and Hartford stroke teams together – where the sum of the collaboration is even more exciting than each part – is poised to make significant contributions to enhance and further the mission of NINDS and StrokeNet to reduce the burden of neurological disease.