Training Program in Lung Biology and Translational Medicine

 描述（由申请人提供）：在肺生物学和转化医学培训计划在伯明翰（UAB）的亚拉巴马大学提供了一个激励和协作的环境，培养高度胜任和创新的生物医学研究科学家的发展多学科培训。该项目于2010年启动，旨在培养医学博士。或博士肺相关研究的博士后研究员，目前已进入第四年，目前有5名受训人员（2-3-4-5-5，1-5年）。在第一个3。在该计划实施的20年中，我们已经毕业了三名学员，他们都在学术研究岗位上，其中两人在全职学术研究教师岗位上，第三人在另一家机构接受高级博士后培训;目前还有五名学员在该计划中。多学科和翻译的方法，以拟议的培训已经非常成功，并强调了由30教师导师谁持有八个UAB部门（4 -基础科学的主要任命多样化和互动组; 4 -临床）。这包括“初级导师”成功过渡到常规教师指导池。教师导师根据科学专业知识分为三个主题领域：（1）免疫学-微生物学;（2）细胞生物学-组织修复;（3）转化科学。统计遗传学、计算生物学、生物标志物发现、药物发现/开发和临床试验（第3组）的转化研究将促进基础科学研究（第1组和第2组）的临床转化。基于UAB现有的专业知识和正在进行的研究工作，培训将侧重于肺部疾病的表现，诊断，风险/预后分层，机制，预防和治疗，主要是急性肺损伤（ALI），囊性纤维化（CF），哮喘，慢性阻塞性肺病（COPD）和间质性肺病（ILD）。培训计划将高度个性化和量身定制，以最大限度地提高每个学员的成功与创建个人发展计划（IDP）。除了将在导师实验室进行的研究项目外，培训还将包括一个高度结构化的教学计划，其中包括肺、过敏和重症监护医学部的每周教学会议，这是一门“生存技能”课程。（与博士后教育的UAB办公室合作）和研究核心课程，包括新兴的主题，如细胞可塑性，药物发现/开发、“大数据”、计算生物学和个性化医疗。正式的指导将包括负责任和道德的研究行为。该方案下一阶段的一个优先事项是招聘/留住代表性不足的少数民族，并保持目前学术生物医学研究职业中受训人员的高保留率。

 DESCRIPTION (provided by applicant): The Training Program in Lung Biology and Translational Medicine at the University of Alabama at Birmingham (UAB) provides multidisciplinary training in a stimulating and collaborative environment that nurtures the development of highly competent and innovative biomedical research scientists. This Program, initiated in 2010 to train M.D. or Ph.D. postdoctoral fellows in lung-related research, is currentl in its 4th year with a current allocation of 5 trainees (2-3-4-5-5, for years 1-5). In the first 3. years of the Program, we have graduated three trainees, all in academic research positions, two of the three are in full-time academic research faculty positions and the third receiving advanced post-doctoral training at another institution; with five additional trainees currently in the Progrm. The multidisciplinary and translational approach to the proposed training has been highly successful, and is highlighted by a diverse and interactive group of thirty faculty mentors who hold primary appointments in eight UAB Departments (4 - basic science; 4 - clinical). This includes the successful transition of "junior mentors" to the regular faculty mentoring pool. The faculty mentors are grouped into three thematic areas based on scientific expertise: (1) immunology-microbiology; (2) cell biology-tissue repair; (3) translational sciences. Translational research in statistical genetics, computational biology, biomarker discovery, and drug discovery/development and clinical trials (group 3) will facilitate the clinical translation of basc science research (groups 1 and 2). Based on the existing expertise and ongoing research efforts at UAB, training will focus on the manifestations, diagnosis, risk/prognostic stratificatio, mechanisms, prevention, and treatment of lung diseases, primarily acute lung injury (ALI), cystic fibrosis (CF), asthma, chronic obstructive lung diseases (COPD), and interstitial lung diseases (ILD). Training programs will be highly individualized and tailored to maximize success of each trainee with the creation of individual development plans (IDPs). In addition to the research projects that will be conducted in the mentor's laboratory, training will encompass a highly structured didactic program that includes weekly teaching conferences in the Division of Pulmonary, Allergy and Critical Care Medicine, a "survival skills" curriculum (in collaboration with the UAB Office of Postdoctoral Education) and a Research Core Curriculum that includes emerging themes such as cellular plasticity, drug discovery/development, "big data", computational biology, and personalized medicine. Formal instruction will include the responsible and ethical conduct of research. A priority in the next phase of this Program is the recruitment/retention of underrepresented minorities, and maintaining the current high-rate of trainee retention in academic biomedical research careers.