2019 International TSC Research Conference

2019年国际TSC研究会议的目标是（1）通过以下方式激发新的研究方向： 使来自外地的受训人员和研究人员了解块茎植物的最新研究进展。 硬化症（TSC），（2）刺激合作研究，以解决未满足的医疗需求，这些 受TSC以及相关疾病影响，包括癫痫、自闭症、淋巴管平滑肌瘤病（LAM）， 和具有重叠表型的罕见疾病。TSC是一种常染色体显性遗传病， 由于TSC 1或TSC 2基因的突变，许多器官中的细胞生长受到异常调节。 为了第一个目标，组委会将（a）赞助为期半天的TSC早期职业研究 研讨会在主要会议开始前的上午，（B）利用旅行奖励， 初级教员到会议参加为期半天的研讨会，分享他们在研究期间的数据 （c）使他们接触到更广泛的研究机会， TSC和相关疾病领域。与TSC的相关性不是选择旅行奖获得者的标准， 鼓励分享不一定是海训方案领域主流的研究概念。15人中至少有3人 将向历来任职人数偏低的群体成员提供旅费。组委会 邀请了10位自2013年以来从未参加过TSC或LAM会议的演讲者。朝向 第二个目标是，会议将（a）将非TSC重点研究人员与TSC专家聚集在一起， 通过提供长时间的休息和用餐时间， 互动，（B）利用分组会议讨论相关的跨学科主题，以及（c）结合 同一届会议-在合理的可能范围内-基础，翻译和临床研究数据， 适用于TSC的神经学、神经心理学和肿瘤生物学方面的假设， 从提交的摘要中挑选资深研究人员以及受训人员和初级研究人员。到 确保提出的概念与以往会议有很大不同，21位受邀演讲者中有16位（76%）没有 在2017年TSC和LAM国际研究会议上发言。以确保新的个人参与 在塑造2019年会议方面，33%（21人中的7人）的受邀演讲者和23%（13人中的3人）的组织者 委员会没有出席2017年TSC和LAM国际研究会议。一个90分钟的关节 包括患者在内的会议将于周六结束，让患者有机会 听取国际TSC调查人员的关键研究，并向他们提问。加拿大的多伦多， 被选为会议地点是因为它可以通过两个国际机场和火车和汽车方便地到达 来自美国东北部和中西部的TS Canada ST董事会成员可以帮助 当地的安排，会议地点是在街对面的医院为生病的儿童，网站的一个 TS联盟认可的TSC诊所和加拿大领先的儿科研究和护理机构之一。

The goals of the 2019 International TSC Research Conference are to (1) inspire new research directions by exposing trainees and researchers from outside the field to the latest research developments in tuberous sclerosis complex (TSC), and (2) stimulate collaborative research to address unmet medical needs of those affected by TSC as well as related disorders, including epilepsy, autism, lymphangioleiomyomatosis (LAM), and rare diseases with overlapping phenotypes. TSC is an autosomal dominant genetic disorder characterized by abnormally regulated cell growth in many organs due to a mutation in either of the TSC1 or TSC2 genes. Toward the first goal, the organizing committee will (a) sponsor a half-day TSC Early Career Research Symposium the morning before the main conference begins, (b) utilize travel awards to bring trainees and junior faculty to the conference to participate in the half-day symposium, share their data during the research conference in platform or poster presentations, and (c) expose them to broader research opportunities in the field of TSC and related disorders. Relevance to TSC is not a criterion for selection of travel award recipients to encourage sharing of research concepts that are not necessarily mainstream in the TSC field. At least 3 of the 15 travel awards will be made to members of traditionally underrepresented groups. The organizing committee invited 10 speakers who have not presented at a TSC or LAM conference going back to 2013. Toward the second goal, the conference will (a) assemble non-TSC-focused researchers together with TSC experts in an environment conducive to sharing data and networking by providing long breaks and mealtimes for interaction, (b) utilize breakout sessions to discuss relevant interdisciplinary topics, and (c) combining in the same session—to the extent reasonably possible—basic, translational, and clinical research data and hypotheses applicable to neurological, neuropsychological, and tumor biological aspects of TSC presented by established researchers alongside trainees and junior researchers to be selected from submitted abstracts. To ensure concepts presented differ greatly from previous conferences, 16 of 21 (76%) invited speakers did not speak at the 2017 International Research Conference on TSC and LAM. To ensure new individuals are involved in shaping the 2019 conference, 33% (7 of 21) of the invited speakers and 23% (3 of 13) of the organizing committee did not attend the 2017 International Research Conference on TSC and LAM. A 90-min joint session including patients will conclude the research conference on Saturday, giving patients an opportunity to hear about key research from, and ask questions of, international TSC investigators. Toronto, Canada, was chosen as the conference site because it is easily accessible via two international airports and by train and car from the Northeastern and Midwestern US, members of the TS Canada ST board of directors can help with local arrangements, and the meeting venue is across the street from The Hospital for Sick Children, the site of a TS Alliance-recognized TSC Clinic and one of Canada’s leading institutions for pediatric research and care.