Biobehavioral Studies of Cardiovascular Disease

摘要 心血管疾病的生物行为研究（PO 1-HL 040962） 这个程序项目（P01）继续应用程序的重点是人类大脑基板的行为和 社会环境对中年人心血管疾病（CVD）风险的影响。计划3个项目 这是概念上的交联和3个核心单元的支持。合作研究者代表 多学科，包括心理学，神经科学，生物物理学，医学，心理神经免疫学， 流行病学、机器学习、生物信息学和统计学。项目1旨在阐明功能和 预测临床前血管疾病多年进展的脑结构表型， 功能障碍，重点是协调自主神经，神经内分泌， 血液动力学和免疫生理学以及与压力和情绪相关的行为过程。项目2的目标 为了确定这些内脏控制回路的功能特征是否缓和了 应激相关环境暴露对临床前血管疾病和功能障碍进展的影响， 跟踪个人在日常生活中的行为和心血管生理，以测试一种新的神经素质模型 CVD风险。项目2还首次测试了日常生活中的身体活动是否与日常生活相关 通过影响内脏控制的神经回路来实现应激生理学。项目3的目标是扩展其他项目的目标 通过阐明将身体活动与生理和心理联系起来的神经和外周过程， 心血管疾病风险的心理生理学标志物（包括日常生活影响和压力生理学）， 实验干预方法这些P01目标在心血管行为医学中是独一无二的， 将在满足所有项目具体要求的多组成部分数据收集工作的背景下开展这些工作。 目标。因此，P01将为人类的综合和转化科学创造新的机会。 神经生物学的CVD风险，跨越多种方法和水平的分析。帮助推进其 P01将产生和传播原始的和广泛的公共领域资源和工具， 通过全面的数据和软件共享， 教育目标。该研究队列包括近900名受试者， 没有临床上明显的CVD的中年人，研究方法将包括以下药物的新组合： 神经影像学、经历环境的生态学瞬时评估、动态血流动力学 监测、自主神经、神经内分泌、免疫和血管评估、实验室临床评价， 异质方法健康行为评估和动脉成像。本P01的3个核心单元规定： 通过行政、数据管理和参与人应计制服务实现协同增效和项目间协调; 测量和仪器支持;以及尖端生物统计和数据密集型方向 （机器学习）分析。因此，本申请代表主题的延续，并且接下来- P01是1988年启动的CVD转化神经生物学研究的一代延伸。

ABSTRACT Biobehavioral Studies of Cardiovascular Disease (PO1-HL040962) This Program Project (P01) continuation application focuses on the human brain substrates of behavioral and socio-environmental influences on cardiovascular disease (CVD) risk in midlife adults. Proposed are 3 Projects that are conceptually cross-linked and supported by 3 Core Units. Collaborative investigators represent multiple disciplines, including psychology, neuroscience, biophysics, medicine, psychoneuroimmunology, epidemiology, machine learning, bioinformatics, and statistics. Project 1 aims to elucidate functional and structural brain phenotypes that predict the multiyear progression of preclinical vascular disease and dysfunction, with a focus on neural circuitries for visceral control that coordinate autonomic, neuroendocrine, hemodynamic, and immune physiology with stress- and emotion-related behavioral processes. Project 2 aims to establish whether functional characteristics of these visceral control circuits moderate the influences of stress-related environmental exposures on the progression of preclinical vascular disease and dysfunction, tracking individuals' behavior and cardiovascular physiology in daily life to test a novel neuro-diathesis model of CVD risk. Project 2 also tests for the first time whether daily life physical activity associates with daily life stress physiology through its effects neural circuits for visceral control. Project 3 aims extend those of the other Projects by elucidating the neural and peripheral processes linking physical activity with physiological and psychophysiological markers of CVD risk (including daily life affect and stress physiology) using an experimental intervention methodology. These P01 aims are unique in cardiovascular behavioral medicine, and they will be pursued in the context of multi-component data collection efforts that satisfy all project-specific aims. As a result, the P01 will create new opportunities for integrative and translational science on the human neurobiology of CVD risk that cuts across multiple methods and levels of analysis. Helping to advance its parent field, the P01 will generate and disseminate original and expansive public-domain resources and tools to the broader scientific and clinical communities through comprehensive data and software sharing and educational objectives. Enabling a precise focus on early CVD etiology, the study cohorts comprise nearly 900 midlife adults without clinically apparent CVD, and study methods will include novel combinations of neuroimaging, ecological momentary assessments of experienced environments, ambulatory hemodynamic monitoring, autonomic, neuroendocrine, immune, and vascular assessments, laboratory clinical evaluations, hetero-method health behavior assessments, and arterial imaging. The 3 Core Units of this P01 provide for synergy and inter-project coordination by administrative, data management and participant accrual services; measurement and instrumentation support; and direction in cutting-edge bio-statistical and data-intensive (machine learning) analyses. The present application thus represents a thematic continuation and next- generation extension of translational neurobiological research on CVD by this P01, which was initiated in 1988.