The impact of obesity on cerebral energetics

项目摘要 有越来越多的证据表明，肥胖与大脑代谢降低有关;然而， 这些观察结果的潜在机制和功能性临床意义仍不清楚。的 该项目的中心目标是调查我们最近的一项发现，即肥胖与 葡萄糖穿过血脑屏障的转运能力降低。这项提案使用了最先进的技术 神经成像技术结合经典的人类代谢表型分析方法， 大脑受肥胖影响的潜在机制。因为大脑对 循环葡萄糖水平，这项研究的结果将有助于澄清大脑如何减少 肥胖症中的葡萄糖转运可能导致餐后饱腹感信号的减少和/或可能是一种潜在的 肥胖的神经认知后果的机制。本R 03提案中的拟议研究将 为未来针对脑葡萄糖转运和代谢改变的研究奠定了基础， 预防肥胖引起的中枢神经系统并发症。

Project summary There is a growing body of evidence that obesity is associated with reduced cerebral metabolism; however, the underlying mechanisms and the functional clinical implications of these observations remain unclear. The central goal of this project is to investigate a finding we have recently made that obesity is associated with decreased transport capacity for glucose across the blood-brain barrier. This proposal uses state of the art neuroimaging technology coupled with classic human metabolic phenotyping methodologies to investigate the underlying mechanisms behind how the brain is impacted by obesity. Because the brain is exquisitely sensitive to circulating glucose levels, the findings from this proposed study will help clarify how diminished brain glucose transport in obesity may lead to diminished post-prandial satiety signaling and/or be a potential mechanism for the neurocognitive consequences of obesity. The proposed studies in this R03 proposal will lay the foundation for future studies targeting brain glucose transport and metabolism alterations to treat and prevent the central nervous system complications of obesity.