African Caribbean Cancer Consortium Scientific and Training Conference

项目摘要/摘要 非洲-加勒比癌症联盟(AC3)是指定的NCI-流行病学和基因组研究机构 (EGRP)联合体。AC3扮演着独特的角色，既照顾非洲裔美国人，也照顾加勒比和非洲人 美国的移民(美国)以及他们的祖国。我们的财团成员是跨国 学科(基础和人口科学研究人员、临床医生和癌症倡导者)，由三个人组成 互联网络(美国、加勒比海和非洲)，涉及40多个机构。我们的2019年会议 主题：“从细胞到社会的方法，以降低非洲人口的癌症风险并改善结果 血统“与我们会员的跨学科构成有关。大规模比较翻译 涵盖分子到人群研究的癌症研究对于加快我们的 在了解和解决癌症差异方面的努力。考虑到美国黑人人口的多样性， 加勒比和非洲的癌症研究也是解决#年癌症差异的重要组成部分。 美国之前的NIH会议支持提供了培训和网络机会，促进了 S在检视和解决多层次因素差距中的作用和责任 影响非洲裔人口的癌症风险、流行病学和预后。初步结果来自 我们2018年的需求评估显示，仍然存在必须消除的差距，以维持 美国-加勒比-非洲的合作。这些差距包括资质、参与和管理的意愿 协作赠款申请，在参与者招募和国家/地区期间获取数据的高效方法 加勒比海和非洲研究人员的分子病理学技能。2019年大会将集中讨论) 解决这些差距和b)为具体的大规模比较翻译制定AC3行动计划 涉及非洲裔美国人、移民以及非洲和加勒比原住民的癌症研究， 利用我们已经建立的资源。这种方法在美国最有好处，因为 比较研究对于了解和改进癌症的干预、治疗和预防至关重要 美国黑人。以下是具体目标：1)促进与癌症风险有关的知识转移和 非洲裔人口的成果，并促进研究研究的发展和协调 涉及非洲裔美国人、非洲裔加勒比人和非洲人。2)促进健康渠道的多样性 通过为代表不足的少数群体提供培训和职业发展的论坛进行差距研究 调查人员和学生。3)通过提供科学严谨的、临床的和文化的 知情的研究和教育，以更大地造福公众，以提高对癌症风险的认识， 降低和预防癌症风险的战略，并产生文化定制的社区响应 服务不足/研究不足人群的研究招募。

PROJECT SUMMARY/ABSTRACT The African-Caribbean Cancer Consortium (AC3) is a designated NCI-Epidemiology and Genomics Research (EGRP) Consortium. AC3 plays a unique role by attending to African American as well as Caribbean and African immigrants in the United States (U.S.) and their native countries. Our consortium membership is trans- disciplinary (basic and population science researchers, clinicians, and cancer advocates) and consists of three interconnected networks (U.S., Caribbean and Africa) involving more than 40 institutions. Our 2019 conference theme “Cell to Society Approaches to Reduce Cancer Risk and Improve Outcomes among Populations of African Ancestry” is relevant to the transdisciplinary makeup of our membership. Large-scale comparative translational cancer research studies that encompass molecular to population-based research are critical to accelerating our efforts in understanding and addressing cancer disparities. Considering the diversity of the U.S Black population, cancer research in the Caribbean and Africa is also an essential component for addressing cancer disparities in the U.S. Prior NIH conference support has provided training and networking opportunities that have facilitated AC3’s growing role and responsibility in examining and addressing disparities involving multi-level factors affecting cancer risk, epidemiology and outcomes of populations of African ancestry. Preliminary results from our 2018 needs assessment reveal that there are still remaining gaps that must be addressed in order to sustain U.S.-Caribbean-Africa collaborations. These gaps include grantsmanship, readiness to participate and manage collaborative grant applications, efficient methods for data capture during participant recruitment and in-country molecular pathology skills for Caribbean and African investigators. The 2019 conference will focus on a) addressing these gaps and b) developing an AC3 action plan for specific large-scale comparative translational cancer research studies involving African Americans, immigrant and native African and Caribbean populations, leveraging on the resources that we have already built. This approach would be most beneficial in the U.S. as comparative studies are critical to inform and improve interventions, treatment and prevention of cancers among U.S. Blacks. The following are the Specific Aims: 1) To facilitate knowledge transfer related to cancer risk and outcomes in African-descent populations, and promote the development and coordination of research studies involving African-American, African-Caribbean and African populations. 2) Promote diversity pipeline for health disparities research by providing a forum for training and career development for under-represented minority investigators and students. 3) To promote health equity by providing scientifically rigorous, clinically and culturally informed research and education for greater public benefit in order to improve knowledge, of cancer risk, strategies for cancer risk reduction and prevention, and generate culturally tailored community responsive research recruitment of underserved/understudied populations.