2019 State of the Science Firefighter Cancer Symposium

项目摘要/摘要 美国消防员患多种癌症的风险增加，最近的一项研究表明 NIOSH的流行病学研究。降低癌症风险对消防部门来说是一个极其重要的问题， 但一些关键障碍，包括开发统一的数据收集工具、暴露 评估，更好地了解癌症机制，有效的癌症筛查和纳入潜在的 为了实现这一目标，必须克服女性消防员等弱势群体。……的通过 将由NIOSH管理的2018年消防员癌症登记法案增加了更具时间敏感性的需求 建立一个协调一致的方法来克服关键障碍。我们已收到部分通知。 由迈阿密大学西尔维斯特综合癌症中心(SCCC)资助，以帮助支持 全国消防癌症研究会议，并制定了消防框架 斗士癌症队列研究(FFCCS)，一项关于消防服务中癌症的多中心前瞻性研究。我们建议 在此基础上，通过完成工作来解决降低消防员癌症风险的关键障碍 以下具体目标：1)支持实施《消防员癌症登记法》；2)建立一个 制定癌症风险调查和未来暴露监测的统一办法；3)确定假定的 与消防员癌症风险升高有关的细胞机制；4)开发一种协调方法 改进消防部门的癌症筛查；以及5)通过以下途径广泛传播研讨会的成果 利益相关者小组、研讨会评估和通过专门研讨会出版科学论文集 网站。这些目标将通过在6月10日组织的消防癌症会议来实现- 2019年11日在迈阿密的SCCC。会议与会者将包括FFCCS监督和 由包括劳工在内的多个消防组织的代表组成的规划委员会， 行政部门、非政府组织和其他亲和力组织，包括但不限于妇女协会，以及 积极研究消防员癌症的学者。NIOSH代表负责组织工作 的消防员将向集合的小组介绍他们的发展需求，他们将开发 满足这些需求的行动计划。协调的消防员癌症风险调查和发展方法 将在当前调查的基础上制定暴露矩阵和暴露报告系统 FFCCS中使用的初步暴露矩阵以及国家消防行动报告系统和 佛罗里达州使用的个人暴露报告。具有毒理学和癌症专业知识的学者 机制将确定潜在的致癌途径，以便在消防服务中进一步评估。学术和 消防部门癌症筛查方面的消防专家将制定研究和实施计划，以 指导今后的努力。拟议的会议将产生一份解决癌症预防研究的路线图 在消防部门，也支持新授权的消防员癌症登记处。

PROJECT SUMMARY / ABSTRACT Firefighters in the United States are at an increased risk for a variety of cancers, as demonstrated by recent epidemiologic studies by the NIOSH. Reduction of cancer risk is an extremely important issue for the fire service, but a number of critical barriers including development of uniform data collection instruments, exposure assessment, better understanding of cancer mechanisms, effective cancer screening and inclusion of potentially vulnerable groups such as women firefighters, must be overcome in order to achieve this goal. The passage of the 2018 Firefighter Cancer Registry Act, to be administered by NIOSH, adds an even more time sensitive need to establishing a coordinated approach to overcoming the critical barriers. We have received notice of partial funding from the Sylvester Comprehensive Cancer Center (SCCC) at the University of Miami to help support a national meeting on cancer research in the fire service, and have also developed the framework for the Fire Fighter Cancer Cohort Study (FFCCS), a multicenter prospective study of cancer in the fire service. We propose to build on this foundation to address the critical barriers to reduction of firefighter cancer risk through completion of the following specific aims: 1) Support implementation of the Firefighter Cancer Registry Act; 2) Establish a unified approach to development of cancer risk surveys and prospective exposure monitoring; 3) Identify putative cellular mechanisms involved in elevated cancer risk in firefighters; 4) Develop a coordinated approach to improving cancer screening in the fire service; and 5) Broad dissemination of symposium findings through stakeholder groups, symposium evaluation and scientific proceedings publication via a dedicated symposium website. These aims will be accomplished through organization of a fire service cancer conference on June 10- 11th, 2019 at the SCCC in Miami. Conference attendees will include members of the FFCCS Oversight and Planning Board, composed of representatives of multiple fire service organizations including labor, administration, NGOs, and other affinity organizations including but not limited to the iWomen, as well as academics with active research addressing firefighter cancer. NIOSH representatives tasked with organization of the Firefighter Cancer Registry will present their development needs to the assembled group, who will develop an action plan to meet these needs. A harmonized firefighter cancer risk survey and approach to development of an exposure matrix and exposure reporting systems will be developed building on the current survey and preliminary exposure matrix used in the FFCCS, as well as the National Fire Operations Reporting System and the Personal Exposure Report used in the state of Florida. Academics with expertise in toxicology and cancer mechanisms will identify potential carcinogenic pathways for further evaluation in the fire service. Academic and fire service experts on cancer screening in the fire service will develop a research and implementation plan to guide future efforts. The proposed conference will result in a roadmap to address cancer prevention research in the fire service, and also support the newly mandated Firefighter Cancer Registry.