Resource-based Center for the study of the joint microenvironment in rheumatology (Overall Application)

总体摘要 我们将在圣地亚哥的加州大学建立风湿病研究资源中心 （加州大学圣地亚哥分校）。我们的关节炎资源MARC（MARC）微环境的主题是促进翻译 研究集中在关节炎的关节微环境上。对原位关节生物学的了解有限， 风湿性疾病的致病机制阻碍了新的生物标志物和治疗方法的发展 针对关节结构内的细胞相互作用。机读目录将通过激发人们对以下方面的兴趣来弥补这一差距： 来自多个国家的资金充足的科学家组成的大型跨学科小组的联合微环境 在圣地亚哥的机构。MARC的目标是为圣地亚哥科学界提供一个 一个全面的本地框架，用于规划、执行和分析各种联合微环境研究 使用侵入性和非侵入性技术，并促进新的，协作的，跨学科的关节炎- 相关研究。该中心的前两个目标是促进组织微环境的研究， 提供（目标1）尖端联合成像技术和方法来分离单细胞， 组织从关节和（目标2）一个专门的计算服务，专注于整合不同的多， 多维数据集。目标3是降低新调查人员进入该领域的障碍， 圣地亚哥以风湿病为重点的科学家之间的合作。这将通过 一项强化计划，包括核心服务券、试点和可行性赠款资金，以及 创建一个新的关节炎系列研讨会和一个以关节炎为重点的区域专题讨论会，以促进合作。 圣地亚哥科学界有着根深蒂固的创造力，活力，协作 翻译的态度和重点。因此，我们的中心将处于独特的地位，以促进新的科学 这对于风湿性疾病的诊断和治疗将是革命性的。

OVERALL ABSTRACT We will establish a Rheumatic Diseases Research Resource Center at the University of California, San Diego (UCSD). The theme of our Microenvironment in Arthritis Resource MARC (MARC) is to facilitate translational research focused on the joint microenvironment in arthritis. Limited knowledge of in situ joint biology and pathogenic mechanisms in rheumatic diseases has prevented development of novel biomarkers and therapies that target cellular interactions within joint structures. The MARC will address this gap by stimulating interest in the joint microenvironment among a large interdisciplinary group of well-funded scientists from multiple institutions in San Diego. The goal of the MARC is to provide the San Diego scientific community with a comprehensive local framework to plan, perform and analyze a large variety of joint microenvironment studies using invasive and non-invasive technology and foster novel, collaborative, and interdisciplinary arthritis- relevant research. The first two Aims of the Center are to facilitate studies on tissue microenvironment by providing access to (Aim 1) cutting-edge joint imaging technology and approaches to isolate single cells and tissue from joints and to (Aim 2) a dedicated computational service focusing on integration of diverse multi- dimensional datasets. Aim 3 is to lower the barrier for new investigators to enter the field and to foster collaboration between rheumatic disease-focused scientists across San Diego. This will be accomplished via an Enrichment Program, which includes vouchers for core services, pilot and feasibility grant funding, and creation of a new arthritis seminar series and a regional arthritis-focused symposium to stimulate collaboration. The San Diego science community has a deeply rooted combination of creativity, dynamism, collaborative attitude and focus on translation. Thus, our Center will be uniquely positioned to facilitate the novel science that will be transformative for the diagnosis and treatment of rheumatic diseases.