FASEB SRC: The Protein Phosphatases Conference

摘要 本申请请求支持2022年版的美国实验学会联合会 生物学(FASE B)夏季蛋白质磷酸酶研究会议。本次大会将是第16届 定期举行的一系列半年度会议的版本，这是北美就这一主题举行的唯一一次会议 自1990年以来一直如此。它的2020版通过R13 CA247237获得了NCI的资助 (得了26分)但不幸的是，由于新冠肺炎大流行和 格兰特被送回了国家情报局。我们现在计划在2022年对其进行重组，作为两家公司的第一次合并 两个历史最悠久的世界磷酸酶会议：FASE B蛋白磷酸酶和 日本蛋白质磷酸酶研究协会(JAPPR)会议(2022年第15届)。这个 会议将为研究人员提供一个热烈而热烈的环境来讨论和探索尖端技术 目前蛋白质磷酸酶的研究领域及其在细胞生物学和人类病理学中的作用。这个 2022年会议旨在1)介绍蛋白质的结构、调节和功能方面的最新工作 特别关注磷酸酶在人类疾病中的作用；2)突出主要成就和新的 方法，产生管道，将它们与其他研究领域相结合，并激发对磷酸酶的兴趣 作为药物靶点；以及3)更新和更新从事新的和 初级科学家和促进FASE B和JAPPR磷酸酶研究之间的联系和合作 社区。为了实现这一目标，2022年的会议旨在涵盖磷酸酶科学的全部范围 从基础到翻译。几个科学会议的重点是一些生物化学和细胞生物学 这些复杂的酶有1000多种形式。专门讨论蛋白磷酸酶作用的会议 在不同的系统和器官中--例如神经系统和免疫系统--提供了理想的杂交平台 对正常组织和病理组织器官的发现进行讨论。癌症将是一个贯穿各领域的主题 会议并将在两会和主旨讲座中特别介绍。新近小说 方法一直在逐步改善磷酸酶的可药性，现在有多种药物在 高级临床试验。因此，另一个交叉主题将是磷酸酶的治疗靶点。 演讲者将包括来自学术界和工业界的专家，以及关于最新进展的演讲和简短的演讲 从提交的摘要中挑选出来的将由新的研究人员、研究生、博士后研究员、 以及来自该领域以外的人，目标是增加女性和少数族裔科学家的代表性。这个 棕榈泉的欧姆尼度假村提供了一个安静的场所，可以促进非正式的互动、讨论和 预计150名参与者之间的合作。总而言之，2022年FASEB会议对 蛋白质磷酸酶将加深我们对基本蛋白质磷酸酶生物学和 为针对磷酸酶的新疗法的开发铺平道路，以改善人类健康。

ABSTRACT This application requests support for the 2022 edition of the Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference on Protein Phosphatases. This conference will be the 16th edition of a recurring series of bi-annual meetings, the sole meeting in North America on this topic held continuously since 1990. Its 2020 edition had been awarded funding from NCI through R13 CA247237 (scored 26) but unfortunately the conference had to be cancelled because of the COVID-19 pandemic and the grant was returned to the NCI. We are planning now to re-organize it in 2022 as the first merger between the two longest-standing world phosphatase conferences: the FASEB protein phosphatase and the Japanese Association for Protein Phosphatase Research (JAPPR) Conference (at its 15th edition in 2022). The conference will provide an intense yet collegial environment for researchers to discuss and explore cutting-edge areas of current research on protein phosphatases and their roles in cellular biology and human pathology. The 2022 conference aims to 1) present the most current work on the structure, regulation and function of the protein phosphatases with particular attention to their roles in human disease; 2) highlight major achievements and new approaches, generate conduits to integrate them with other fields of research, and fuel interest in phosphatases as drug targets; and 3) to renew and refresh the community of phosphatase researchers engaging new and junior scientists and facilitating ties and collaboration between the FASEB and JAPPR phosphatase research communities. To achieve this, the 2022 conference is designed to cover the whole range of phosphatase science from basic to translational. Several scientific sessions are focused on the biochemistry and cell biology of some of the more than 1000 forms of these complex enzymes. Sessions dedicated to the role of protein phosphatases in diverse systems and organs—e.g. the nervous and immune systems- provide ideal platforms for cross- discussion of findings in normal vs pathological tissues and organs. Cancer will be a cross-cutting theme of the conference and will also be especially featured in two sessions and in the keynote lectures. Recent novel approaches have been progressively improving druggability of phosphatases, with multiple agents now in advanced clinical trials. Thus, another cross-cutting theme will be therapeutic targeting of phosphatases. Speakers will include experts from academia and industry, and talks on late-breaking advances and short talks selected from submitted abstracts will be given by new investigators, graduate students, post-doctoral fellows, and those from outside the field with a goal of increasing representation by women and minority scientists. The Omni Resort in Palm Springs provides a secluded venue that fosters informal interaction, discussion, and collaboration between the expected 150 participants. Altogether, the impact of the 2022 FASEB Conference on Protein Phosphatases will be to augment our understanding of fundamental protein phosphatase biology and pave the way for development of new therapies targeting phosphatases to improve human health.