FASEB SRC: The Protein Phosphatases Conference

摘要 此应用程序请求支持2022年版的美国实验学会联合会 生物学（FASEB）蛋白磷酸酶夏季研究会议。本次会议将是第16届 一年两次的一系列定期会议，这是在北美举行的关于这一主题的唯一会议。 自1990年以来一直。其2020年版已通过R13 CA 247237获得NCI的资助 （得分26）但不幸的是，由于COVID-19大流行和 补助金已退还给NCI。我们现在计划在2022年重新组织它，作为第一次合并， 两个历史最悠久的世界磷酸酶会议：FASEB蛋白磷酸酶和 日本蛋白磷酸酶研究协会（JAPPR）会议（2022年第15届）。的 会议将为研究人员提供一个紧张而又合议的环境，讨论和探索尖端的 蛋白磷酸酶及其在细胞生物学和人类病理学中的作用。的 2022年会议的目的是：1）介绍有关蛋白质结构，调节和功能的最新工作 磷酸酶，特别注意其在人类疾病中的作用; 2）突出主要成就和新的 方法，产生管道，将它们与其他研究领域相结合，并激发对磷酸酶的兴趣 作为药物靶点;和3）更新和刷新磷酸酶研究人员的社区， 青年科学家和促进FASEB和JAPPR磷酸酶研究之间的联系和合作 社区.为了实现这一目标，2022年会议旨在涵盖磷酸酶科学的整个范围 从基础到翻译。几个科学会议的重点是生物化学和细胞生物学的一些 这些复杂酶的1000多种形式。蛋白质磷酸酶的作用 在不同的系统和器官，如神经和免疫系统，提供了理想的平台， 讨论正常与病理组织和器官中的发现。癌症将是2010年世界癌症日的一个跨领域主题。 会议，也将特别是在两个会议和主题演讲。新小说 已经有方法逐步改善磷酸酶的药物可药性，现在有多种药物可用于治疗磷酸酶。 先进的临床试验因此，另一个交叉主题将是磷酸酶的治疗靶向。 演讲者将包括来自学术界和工业界的专家，并就最新进展和简短会谈进行会谈 从提交的摘要中选择将由新的研究人员，研究生，博士后研究员， 以及那些来自该领域以外的人，其目标是增加女性和少数民族科学家的代表性。的 棕榈泉的Omni度假村提供了一个僻静的场所，可以促进非正式的互动，讨论， 预计将有150名参与者。总的来说，2022年FASEB会议对 蛋白磷酸酶将增加我们对基本蛋白磷酸酶生物学的理解， 为开发针对磷酸酶的新疗法以改善人类健康铺平道路。

ABSTRACT This application requests support for the 2022 edition of the Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference on Protein Phosphatases. This conference will be the 16th edition of a recurring series of bi-annual meetings, the sole meeting in North America on this topic held continuously since 1990. Its 2020 edition had been awarded funding from NCI through R13 CA247237 (scored 26) but unfortunately the conference had to be cancelled because of the COVID-19 pandemic and the grant was returned to the NCI. We are planning now to re-organize it in 2022 as the first merger between the two longest-standing world phosphatase conferences: the FASEB protein phosphatase and the Japanese Association for Protein Phosphatase Research (JAPPR) Conference (at its 15th edition in 2022). The conference will provide an intense yet collegial environment for researchers to discuss and explore cutting-edge areas of current research on protein phosphatases and their roles in cellular biology and human pathology. The 2022 conference aims to 1) present the most current work on the structure, regulation and function of the protein phosphatases with particular attention to their roles in human disease; 2) highlight major achievements and new approaches, generate conduits to integrate them with other fields of research, and fuel interest in phosphatases as drug targets; and 3) to renew and refresh the community of phosphatase researchers engaging new and junior scientists and facilitating ties and collaboration between the FASEB and JAPPR phosphatase research communities. To achieve this, the 2022 conference is designed to cover the whole range of phosphatase science from basic to translational. Several scientific sessions are focused on the biochemistry and cell biology of some of the more than 1000 forms of these complex enzymes. Sessions dedicated to the role of protein phosphatases in diverse systems and organs—e.g. the nervous and immune systems- provide ideal platforms for cross- discussion of findings in normal vs pathological tissues and organs. Cancer will be a cross-cutting theme of the conference and will also be especially featured in two sessions and in the keynote lectures. Recent novel approaches have been progressively improving druggability of phosphatases, with multiple agents now in advanced clinical trials. Thus, another cross-cutting theme will be therapeutic targeting of phosphatases. Speakers will include experts from academia and industry, and talks on late-breaking advances and short talks selected from submitted abstracts will be given by new investigators, graduate students, post-doctoral fellows, and those from outside the field with a goal of increasing representation by women and minority scientists. The Omni Resort in Palm Springs provides a secluded venue that fosters informal interaction, discussion, and collaboration between the expected 150 participants. Altogether, the impact of the 2022 FASEB Conference on Protein Phosphatases will be to augment our understanding of fundamental protein phosphatase biology and pave the way for development of new therapies targeting phosphatases to improve human health.