Male Chlamydia infections: The key role of macrophages in testicular dissemination and disrupted spermatogenesis

寻求试管婴儿的夫妇的男性伴侣，谁是衣原体血清阳性，表明以前的感染，往往有显着受损的精子质量（活力降低，DNA损伤增加和精子形态异常）。我们的研究将确定衣原体如何从阴茎运输到睾丸，以及睾丸中的慢性衣原体感染如何破坏精子发育。我们还将开发新的抗生素输送系统，以改善对男性衣原体感染的治疗。

Male partners of couples seeking IVF, who are seropositive for Chlamydia, indicating a prior infection, often have significantly impaired sperm quality (reduced motility, increased DNA damage and abnormal sperm morphology). Our studies will define how Chlamydia are transported to the testis from the penis and how chronic chlamydial infection in the testis disrupts sperm development. We will also develop new antibiotic delivery systems to improve treatment of male chlamydial infections.