Cancer Prevention: Staging my career as a cancer biologist

黑色素瘤是最致命的皮肤癌，其发病率每年都在增加，并且由于治疗失败而预后不良。 一级和二级预防战略。黑色素瘤治疗策略通常 由于患者的内在或获得性耐药性而不成功，突出了对新的，次要的 预防-干预战略，具有经过充分验证的机械目标。因此，我的职业目标是 成为一个独立的，学术黑色素瘤研究人员，重点是转化科学，以发展 针对黑色素瘤的策略。为了确保这一结果，所附的全面研究，指导， 职业发展计划将在博士前和博士后奖学金期间实施 培训期间。 我的总体假设是，目标导向的研究和职业发展，在我的博士前和 多年的博士后培训将使我成为一个独立的，学术的黑素瘤 研究员以下目标将解决这一假设： 目的1：论文研究项目-目标，基本原理，假设，和迄今为止的进展。 目标2：论文研究项目-工作要完成。 目标3：博士后研究方向。 我的博士前研究是重要的，因为它提供了关于差异作用的关键知识， 氧化应激、自噬和p62调节作为黑色素瘤发展的生存机制， 黑色素瘤治疗靶向的潜力。此外，研究期间获得的技术技能， 博士前阶段将积极影响我的博士后研究培训，因为我学会了评估的机制， 黑色素瘤的发展、预防策略和体内治疗靶向。我提议的结果 研究还将通过制定治疗策略对公共卫生产生积极影响， 黑素瘤建议的职业发展计划将有助于我作为博士后研究员的培养 并随后过渡到一个研究教师的位置。总体而言，概述的双阶段研究金培训 当我继续为改进做出贡献时，该计划无疑将促进我的研究和职业发展 作为一名公认的转化癌症研究人员。

Melanoma is the deadliest skin cancer with yearly increasing incidence and poor prognosis due to failure of both primary and secondary prevention strategies, respectively. Melanoma treatment strategies are often unsuccessful due to patients’ intrinsic or acquired drug resistance, highlighting the need for novel, secondary prevention-intervention strategies with thoroughly validated mechanistic targets. Therefore, my career goal is to become an independent, academic melanoma researcher, with a focus in translational science to develop strategies to target melanoma. To ensure this outcome, the enclosed comprehensive research, mentoring, and career development plans will be implemented over the course of the predoctoral and postdoctoral fellowship training periods. My overall hypothesis is that goal-oriented research and career development in my predoctoral and postdoctoral training years will lead me to establish myself as an independent, academic melanoma researcher. The following aims will address this hypothesis: Aim 1: The Dissertation Research Project – goal, rationale, hypotheses, and progress thus far. Aim 2: The Dissertation Research Project – work to be completed. Aim 3: The Postdoctoral Research Direction. My predoctoral research is significant because it provides critical knowledge about the differential role of oxidative stress, autophagy, and p62 regulation as survival mechanisms for melanoma development and the potential for therapeutic targeting in melanoma. Further, the research technical skills acquired during the predoctoral phase will positively impact my postdoctoral research training as I learn to evaluate mechanisms of melanoma development, prevention strategies and therapeutic targeting in vivo. The results of my proposed research studies will also positively impact public health by development of therapeutic strategies for melanoma. The proposed career development plan will be instrumental for my training as a postdoctoral fellow and subsequent transition to a research faculty position. Overall, the outlined dual-phase fellowship training plan will undoubtedly facilitate my research and career development as I continue to contribute to improving public health as an established translational cancer researcher.