2020 Plasminogen Activation and Extracellular Proteolysis Gordon Research Conference and Gordon Research Seminar

总结 部分支持是要求研究生和博士后研究员，初级和中级职业教师 参加戈登研究研讨会和会议（GRS/GRC）题为“纤溶酶原激活 和细胞外蛋白水解”，将于2020年2月8日至9日和9日至14日在加利福尼亚州文图拉举行。这将是 第16届GRC，自1990年以来，该会议每两年连续举行一次。的重点 2020年GRC将研究细胞外蛋白水解酶的机制和功能，如纤维蛋白（原）， 凝血酶、纤溶酶（原）、纤溶酶原激活剂、它们的前体和效应物。最近的数据显示， 这些血液蛋白酶的表达可能与与正常和病理性 流程.我们邀请的演讲者和讨论领导者将介绍他们最近和正在出现的工作， 重点将放在这些蛋白质在病理生理事件，包括恶化的作用， 脑血管功能与衰老，凝血功能障碍和脑缺血，肌肉骨骼和 与纤维蛋白沉积、癌症发展、炎性 疾病，以及针对这些疾病的新疗法的技术进步。之一 2020年GRC会议的主要目标是将基础研究转化为临床。与会者将被选中 通过邀请和在线提交的申请。他们将被选中代表不同的光谱， 研究，并将大力强调妇女和科学家的参与， 组这次会议的一个预期优势将是青年科学家之间的互动和联网， 现场，与讨论领导人和发言人。相关的GRS，这是一个更年轻的功能， 将为学员和科学家提供一个分享GRC经验的独特机会。 这个为期两天的研讨会将由研究生和博士后研究员组织，并得到以下机构的支持： 领先的研究人员和GRC椅子，并将允许纤溶酶原领域的初级研究人员 激活和细胞外蛋白水解走到一起，讨论他们目前的研究，同时建立 他们与同行的非正式网络，可能会导致一生的合作和科学成就。

Summary Partial support is requested for graduate students and post-doctoral fellows, and junior and midcareer faculty to participate in the Gordon Research Seminar and Conference (GRS/GRC) entitled “Plasminogen Activation and Extracellular proteolysis”, which will be held in Ventura, CA on February 8-9 and 9-14, 2020. This will be the 16th GRC, as the conference has been held continuously every two years since 1990. The focus of the 2020 GRC will be on mechanisms and functions of extracellular proteolytic enzymes, such as fibrin(ogen), thrombin, plasmin(ogen), plasminogen activators, their precursors and effectors. Recent data suggest that the expression of these blood proteases may be related to diseases associated with normal and pathological processes. Our invited speakers and discussion leaders will present their recent and emerging work, and emphasis will be placed on the roles of these proteins in pathophysiological events including deteriorating cerebrovascular function with aging, coagulopathies and cerebral ischemia, musculoskeletal and neurodegenerative diseases associated with depositions of fibrin, development of cancer, inflammatory diseases, and the technological advances in targeting them for the generation of new treatments. One of the major goals for the 2020 GRC meeting is translating basic research into the clinic. Attendees will be selected by invitation and from applications submitted online. They will be chosen to represent a diverse spectrum of research, and a strong emphasis will be made on the inclusion of women and scientists from underrepresented groups. An intended strength of this meeting will be the interaction and networking of the young scientists in the field, with the discussion leaders and the speakers. The associated GRS, which is a much younger feature of the conference, will provide a unique opportunity for trainees and scientists to share in the GRC experience. This two-day seminar will be organized by Graduate Students and Postdoctoral Fellows with the support of leading researchers and the GRC Chairs, and will allow junior researchers within the field of plasminogen activation and extracellular proteolysis to come together to discuss their current research, while building informal networks with their peers that may lead to a lifetime of collaboration and scientific achievement.