MODULATION OF CARDIAC NAV CHANNEL FUNCTION AND ELECTROPHYSIOLOGY BY INTERACTING MOLECULES

摘要 在可兴奋细胞中，电压门控Na+通道启动动作电位。近年来 发现这些通道由多个部分组成，形成一个大分子 信号复合体这些不同的部分精确地调节Na+通道对细胞的功能 他们居住的地方。该提案旨在开始发现一个人如何 Na+通道是Na+通道的重要组成部分，也是调节Na+通道功能和药理学的重要分子。如果 建议的目标成功，这种新的理解可以提供一种更有效的途径， 用于兴奋性障碍如心律失常和癫痫的精确定向疗法。

Abstract In excitable cells, voltage-gated Na+ channels initiate the action potential. In recent years, it has been discovered that these channels are composed of many parts to form a macromolecular signaling complex. These different parts precisely tune the function of Na+ channels to the cells that they reside in. This proposal aims to begin to discover mechanisms of how one component, the β-subunits, modulate the function and pharmacology of Na+ channels. If the proposed aims succeed, this new understanding could provide a route to more effective and precisely-directed therapies for excitability disorders such as arrhythmia and epilepsy.